Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)

doi:10.1186/1471-2164-9-78

BMC Genomics
Volume 9

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Research article

Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)

Robert B Page^*¹^,2 , Stephen R Voss^*¹^,2 , Amy K Samuels¹^,2 , Jeramiah J Smith¹^,2 , Srikrishna Putta¹^,2 and Christopher K Beachy³^,4

¹Department of Biology, University of Kentucky, Lexington Kentucky, 40506 USA

²Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506 USA

³Department of Biology, Minot State University, Minot, North Dakota, 58707 USA

⁴Amphibian Growth Project, Minot State University, Minot, North Dakota, 58707 USA

author email corresponding author email* Contributed equally

BMC Genomics 2008, 9:78doi:10.1186/1471-2164-9-78


Published:	11 February 2008

Additional files

Additional file 1:

Analysis of the effect of time in the absence of T₄. Excel table containing statistical and informatic values associated with the analysis of the effect of time in the absence of T₄.

Format: XLS Size: 897KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

Description of the effect of time in the absence of T₄. Word document containing descriptions of the column headers in Additional file 1.

Format: DOC Size: 30KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 3:

DEGs identified by contrasting the T₄concentrations at each non-zero time point. Excel table containing statistical and informatic values for the DEGs identified by contrasting the 5 and 50 nM T₄treatments at Days 2, 12, and 28 and imposing fold change criteria.

Format: XLS Size: 288KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 4:

Description of the DEGs identified by contrasting the T₄concentrations at each non-zero time point. Word document containing descriptions of the column headers in Additional file 3.

Format: DOC Size: 44KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 5:

DEGs identified by the 5 nM regression analysis. Excel table containing statistical and informatic values for the DEGs identified by conducting linear and quadratic regression on the 5 nM dataset and imposing fold change criteria.

Format: XLS Size: 327KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 6:

Description of the DEGs identified by the 5 nM regression analysis. Word document containing descriptions of the column headers in Additional file 5.

Format: DOC Size: 44KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 7:

DEGs identified by the 50 nM regression analysis. Excel table containing statistical and informatic values for the DEGs identified by conducting linear and quadratic regression on the 50 nM dataset and imposing fold change criteria.

Format: XLS Size: 422KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 8:

Description of the DEGs identified by the 50 nM regression analysis. Word document containing descriptions of the column headers in Additional file 7.

Format: DOC Size: 44KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 9:

The 79 genes unique to the 5 nM regression analysis. Excel table containing statistical and informatic values for the 79 DEGs identified by the 5 nM regression analysis and fold change criteria that were not identified by the 50 nM regression analysis.

Format: XLS Size: 96KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 10:

Description of the 79 genes unique to the 5 nM regression analysis. Word document containing descriptions of the column headers found in Additional file 9.

Format: DOC Size: 47KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 11:

The 246 genes unique to the 50 nM regression analysis. Excel table containing statistical and informatic values for the 246 DEGs identified by the 50 nM regression analysis and fold change criteria that were not identified by the 5 nM regression analysis.

Format: XLS Size: 250KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 12:

Description of the 246 genes unique to the 50 nM regression analysis. Word document containing descriptions of the column headers found in Additional file 11.

Format: DOC Size: 45KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 13:

The 111 genes identified as differentially expressed in axolotl epidermis and Xenopus intestine. Excel table containing statistical and informatic values for the genes identified as differentially expressed in axolotl epidermis and Xenopus intestine.

Format: XLS Size: 111KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 14:

Description of the 111 genes identified as differentially expressed in axolotl epidermis and Xenopus intestine. Word document containing descriptions of the column headers in Additional file 13.

Format: DOC Size: 45KB Download file

This file can be viewed with: Microsoft Word Viewer