Table 5

Evolutionary conservation of variants seen between M. Spretus strains

Gene

Variant

HS

RN

GG

BT

CF

XT

MD

SIFT


Lamb1-1

Gly1334Asn

Asp

Asp

NH

NH

Asp

NH

NH

0.47


Cog5

Asp538Glu

Asp

Asp

Asp

Asp

Asp

NH

Glu

1


Asp742Glu

Ser

NH

Asn

Ser

Ser

NH

Arg

0.92


1110049B09rik

Pro691Ala

Pro

Lys

Pro

Pro

Pro

Pro

Pro

0.11


F730043M19Rik

Ser115Leu

NH

NH

NH

NH

NH

NH

NH

0.21


Asn133Ile

NH

NH

NH

NH

NH

NH

NH

0.00


Twistnb

Asn322Asp

Glu

Asn

Glu

Glu

Glu

Asn

Leu

0.39


Hdac9

Ile265Met

Ile

Ile

Leu

Thr

Ile

Leu

Leu

0.33


Gly749Ser

Gly

Gly

Gly

Gly

NH

NH

Ala

1.00


Ala994Val

Val

Ala

Ile

Val

NH

NH

Ile

1.00


Ahr

Asn533Ser

Ser

Ser

Ser

Asn

Ser

Asn

Leu

1.00


Asn544Asp

Asp

Asp

Asn

Phe

Asp

Asp

Gly

0.66


EG629820

Gly47Ser

NH

NH

NH

NH

NH

NH

NH

0.00


Gly70Ser

NH

NH

NH

NH

NH

NH

NH

0.00


Asn72Tyr

NH

NH

NH

NH

NH

NH

NH

0.00


Zfp277

Gln21Phe

Gln

NH

Gln

Gln

Gln

Gln

NH

0.15


Val434His

Ser

NH

NH

Asn

Arg

NH

Asp

0.08


Lrrn3

Ala69Gln

Ala

Ala

Ala

Ala

Ala

NH

Gln

0.08


Leu670Val

Phe

Leu

Ile

Phe

Phe

NH

Ile

0.23


Ala671Val

Ala

Ala

Ser

Ala

Thr

NH

Phe

0.15


DnaJB9

Phe10Leu

Phe

Phe

Phe

Phe

Phe

Phe

Ala

1.00


NrCam

Gln152Arg

Gln

Arg

Arg

Arg

Arg

Gln

Phe

0.49


Bold indicates significant SIFT scores. No known homology (NH), No sift score generated (NSS) M. musculus (MM) Homo sapiens (HS), Rattus norvegicus (RN), Gallus gallus (GG), Bos Taurus (BT), Canis familiaris (CF), Xenopus tropicalis (XP), and Monodelphis domestica (MD).

Mahler et al. BMC Genomics 2008 9:626   doi:10.1186/1471-2164-9-626

Open Data