Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations

doi:10.1186/1471-2164-9-625

BMC Genomics

Volume 9

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Research article

Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations

Krishanpal Anamika¹^* , Juliette Martin¹^,2^,3^* and Narayanaswamy Srinivasan¹

¹Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

²INRA UR1077, Unité Mathématique Informatique et Génome, F-78350 Jouy-en-Josas, France

³Université de Lyon, Lyon, France; Université Lyon 1; IFR 128; CNRS, UMR 5086; IBCP, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, Lyon, F-69367, France

author email corresponding author email* Contributed equally

BMC Genomics 2008, 9:625doi:10.1186/1471-2164-9-625


Published:	23 December 2008

Additional files

Additional file 1:

Chimpanzee kinases with their subfamily classification, number of residues in the gene product and domains present.

Format: RTF Size: 928KB Download file

Additional file 2:

Sequence alignment between some of the closest chimp and human kinase pairs with difference in domain architecture.

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Additional file 3:

List of chimpanzee protein kinases and their putative orthologues in human. The Hanks and Hunter protein kinase subfamily to which chimp kinases belong is also mentioned.

Format: RTF Size: 500KB Download file

Additional file 4:

The table representing different gene expression levels for human and chimp protein kinases in five different tissue types.

Format: RTF Size: 226KB Download file

Additional file 5:

Population and distribution of chimpanzee protein kinases into various subfamilies.

Format: RTF Size: 65KB Download file