Overrepresented miRNA regulatory pathways in PKD. Fisher's exact test was used to identify significant enrichment for pathway annotations among predicted targets of dysregulated miRNAs and differentially expressed mRNAs in PKD. Pathways (from KEGG, MSigDB, Biocarta, GO) have been grouped in larger functional categories according to the KEGG annotation. The pie-chart shows 22 functional categories and each pie represents a functional category with an overrepresentation of regulatory pathways of miRNA targets as well as mRNAs. Only pathways overlapped from the functional patterns of predicted miRNA targets and differentially expressed mRNAs are shown.
Pandey et al. BMC Genomics 2008 9:624 doi:10.1186/1471-2164-9-624