Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
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* Corresponding author: Clare Strode c.strode@liv.ac.uk
BMC Genomics 2008, 9:538 doi:10.1186/1471-2164-9-538
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BioMed Central: 6 citations
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Alphonsine A Koffi, Ludovic Alou, Maurice A Adja, Moussa Koné, Fabrice Chandre, Raphael N'Guessan Parasites & Vectors 2012, 5:68 (2 April 2012) The results presented here show that insecticide resistance in the S form of An. gambiae s.s. is multifactorial at this locality and includes, in addition to target site mutations, enhanced metabolic mechanism components never identified before. At least four resistance mechanisms were found: high frequency of the L1014F kdr, ace-1R and increased activity of NSE and GSTs.
Image: A description of bioassay experiments during susceptibility test at IPR facilities.
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Corine Ngufor, Raphael N'Guessan, Pelagie Boko, Abibatou Odjo, Estelle Vigninou, Alex Asidi, Martin Akogbeto, Mark Rowland Malaria Journal 2011, 10:343 (16 November 2011) A very relevant paper given the prevailing malaria vector control landscape where there are emerging reports of pyrethroid insecticide resistance among malaria vectors across Africa at a rate never experienced before.
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Innocent Djègbè, Olayidé Boussari, Aboubakar Sidick, Thibaud Martin, Hilary Ranson, Fabrice Chandre, Martin Akogbéto, Vincent Corbel Malaria Journal 2011, 10:261 (12 September 2011) Pyrethroid and DDT resistance is widespread in malaria vector in Benin and both metabolic and target site resistance are implicated. Resistance was not correlated with a change of malaria species and/or molecular forms. The L1014S kdr allele was first identified in wild population of An. gambiae s.s and An. arabiensis hence confirming the expansion of pyrethroid resistance alleles in Africa.
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Research article
Plasmodium infection alters Anopheles gambiae detoxification gene expression Rute C Félix, Pie Müller, Vera Ribeiro, Hilary Ranson, Henrique Silveira BMC Genomics 2010, 11:312 (19 May 2010) |
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Jean-Philippe David, Eric Coissac, Christelle Melodelima, Rodolphe Poupardin, Muhammad Riaz, Alexia Chandor-Proust, Stéphane Reynaud BMC Genomics 2010, 11:216 (31 March 2010) |
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Armel Djènontin, Joseph Chabi, Thierry Baldet, Seth Irish, Cédric Pennetier, Jean-Marc Hougard, Vincent Corbel, Martin Akogbéto, Fabrice Chandre Malaria Journal 2009, 8:233 (20 October 2009) This paper addresses a topic of major importance in the control not only of malaria vectors but other disease vectors. Resistance is becoming more widespread and the disease control community looks for ways to combat resistance, either through development of new technologies or novel ways in which to deliver insecticides.
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