Table 1

Top 10 canonical pathways influenced by fasting

pathway

pathway group

p- value

genes


glycolysis and gluconeogenesis

metabolic maps/carbohydrate metabolism

2.32e-07

9/36

urea cycle

metabolic maps/amino-acid metabolism

2.61e-07

8/27

PPARα regulation of lipid metabolism

regulation of metabolism/regulation of lipid metabolism

3.57e-07

8/28

peroxisomal straight-chain fatty-acid β-oxidation

metabolic maps/lipid metabolism

2.51e-06

5/10

mitochondrial long-chain fatty- acid β-oxidation

metabolic maps/lipid metabolism

2.74e-06

6/17

metabolism of sulphur-containing amino acids

metabolic maps/amino-acid metabolism

4.02e-06

6/18

peroxisomal branched-chain fatty- acid oxidation

metabolic maps/lipid metabolism

8.04e-06

6/20

taurine metabolism

metabolic maps/amino-acid metabolism

1.96e-05

6/23

mitochondrial unsaturated fatty- acid β-oxidation

metabolic maps/lipid metabolism

2.69e-05

5/15

TCA

metabolic maps/amino-acid metabolism

1.25e-04

4/20


Canonical pathways represent a set of about 500 signalling and metabolic maps in the MetaCore suit. All maps are drawn from scratch by GeneGo annotators and manually curated.

Sokolović et al. BMC Genomics 2008 9:528   doi:10.1186/1471-2164-9-528

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