Relationship between overall FDR, local fdr, and the number of predicted differentially expressed genes. We chose a 30% local fdr as a threshold resulting in 309 differentially expressed genes (corresponding to a 21.4% overall FDR). Additional genes selected would be at a higher 'opportunity cost' as the local fdr is higher than 30% for the next 100 genes.
Juskeviciute et al. BMC Genomics 2008 9:527 doi:10.1186/1471-2164-9-527