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A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum

Karine G Le Roch*, Jeffrey R Johnson, Hugues Ahiboh, Duk-Won D Chung, Jacques Prudhomme, David Plouffe, Kerstin Henson, Yingyao Zhou, William Witola, John R Yates, Choukri B Mamoun, Elizabeth A Winzeler and Henri Vial

BMC Genomics 2008, 9:513 doi:10.1186/1471-2164-9-513

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Research   Open Access Highly Accessed

Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine

Kanyanan Kritsiriwuthinan, Sastra Chaotheing, Philip J Shaw, Chayaphat Wongsombat, Porntip Chavalitshewinkoon-Petmitr, Sumalee Kamchonwongpaisan Malaria Journal 2011, 10:242 (18 August 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In this study, the authors used a DNA microarray to analyse the gene expression profile of a CQ resistant strain of Plasmodium falciparum after IC50 doses of either pyronaridine (or chloroquine. The transcription profiles are compared.

Methodology article   Open Access Highly Accessed

High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery

Serena Cervantes, Jacques Prudhomme, David Carter, Krishna G Gopi, Qian Li, Young-Tae Chang, Karine G Le Roch BMC Cell Biology 2009, 10:45 (10 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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