Table 2

Genes specific to affected tissues in Foxa2 mutants are enriched for Gene Ontology (GO) terms.

Affected tissues

GO Term

Specific Term

GO ID

P value* (Average)

E value

Gene Hits (Number)

Gene Hits (Symbols)


Primary:

Molecular

function

transcription factor activity

GO:0003700

0.002335

5.08

5

Foxa1

Foxa2

-node

Foxd4

-notochord

Sox17

-anterior

T

mesendoderm

Biological

process

anterior/posterior pattern

formation

GO:0009952

0.000362

21.11

3

Cer1

-definitive endoderm

Biological

process

morphogenesis of an epithelium

GO:0002009

0.000432

19.87

3

Foxa2

T

Foxa1

Foxa2

T

Biological

process

gastrulation

GO:0007369

0.003025

24.25

2

Cer1

Foxa2

Biological

process

notochord development

GO:0030903

0.006329

157.63

1

T


Secondary:

Molecular function

transcription factor activity

GO:0003700

0.000053

4.49

10

Cdx1

Foxb1

-primitive streak

Gbx2

-cardiac mesoderm

Hesx1

-anterior neuroectoderm

Hoxa1

-vasculature

Meis1

Meox1

Nkx1-2

Six3

Tbx6

Biological process

anterior/posterior pattern formation

GO:0009952

0

21.77

7

Aldh1a2

Dll1

Gbx2

Hoxa1

Meox1

Six3

Wnt3a

Biological process

cardiac muscle morphogenesis

GO:0055008

0.00012

116.09

2

Actc1

Tnnt2

Biological process

forebrain development

GO:0030900

0.000392

11.51

4

Aldh1a2

Fabp7

Six3

Wnt3a


*significance for GO term enrichment: p ≤ 0.01

Tamplin et al. BMC Genomics 2008 9:511   doi:10.1186/1471-2164-9-511

Open Data