Figure 5.

Phylogenetic tree of ASMTL proteins. Human ASMTL [GenBank:NP_004183] was used as a seed to search the GenBank NR database for orthologs and an approximate maximum-likelihood tree was generated. The putative mouse ASMTL lacks the ASMT domain and clusters well outside the mammalian clade, indicating that it has considerably diverged compared to the putative ancestor. Entries are annotated with species, chromosome (where known) and GenBank Accession number.