Table 4

Known function of immune system GPCRs

Cytokine receptors

Chemokine (C-C motif) receptor 5

Stimulates leukocyte chemotactic activity

Chemokine (C-C motif) receptor 6

Associated with mature memory B cells

Chemokine (C-X-C motif) receptor 3 splice 2

Transduction of angiostatic effect of cytokines in microvascular endothelial cells

Chemokine (C-X-C motif) receptor 4

Neuronal survival; maintaining of highly differentiated neurons; axon guidance

Chemokine (C-X-C motif) receptor 7

Co-receptor for CXCR4 in B-, T-cells and monocytes

Chemokine (C-X-C motif) receptor 5

B-cell activation and chemoattraction

Non-cytokine receptors

EBV-induced G-protein coupled receptor 2

B-lymphocyte and promyelocytic (glial precursor) cell line regulation

GPR34

Lysophosphatidylserine receptor in mast cells; wound healing

GPR81

Exclusively expressed in T-cells; neurotensin-related

GPR132

Mitosis delay under control of lysophosphatidylcholine in lymphocytes and macrophages

Leukotriene B(4) receptor 2

Chemotaxis of mononuclear lymphocytes

Prostaglandin E2 receptor EP4 (PTGER4)

Stimulates immune response in B-cells and monocytes

P2Y10 (putative nucleotide receptor)

Monocyte development

GPCRs related to immune system expressed in fish olfactory epithelium.

Kolmakov et al. BMC Genomics 2008 9:429   doi:10.1186/1471-2164-9-429