Interspecies data mining to predict novel ING-protein interactions in human

doi:10.1186/1471-2164-9-426

BMC Genomics
Volume 9

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Sensen CW
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Research article

Interspecies data mining to predict novel ING-protein interactions in human

Paul MK Gordon^*¹ , Mohamed A Soliman^*¹^,2^,3 , Pinaki Bose¹^,2 , Quang Trinh¹ , Christoph W Sensen¹ and Karl Riabowol¹^,2

¹Department of Biochemistry & Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

²Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

³Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

author email corresponding author email* Contributed equally

BMC Genomics 2008, 9:426doi:10.1186/1471-2164-9-426


Published:	18 September 2008

Additional files

Additional file 1:

Pairwise similarity of ING family proteins in yeast and human. Using various alignment algorithms, we found that YNG1 is the ortholog of human ING1/2, YNG2 is the closest homolog to human ING4/5, and PHO23 (YNG3) is similar to human ING3.

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Additional file 2:

Potential yeast ING-interacting proteins with human homologs. Using the taxonomic tool in MAGPIE, we filtered the list of 1075 yeast ING-interacting proteins to only those having human homologs with e-value < 10^-35, yielding 381 potential conserved interactions in human.

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Additional file 3:

Evidence for potential ING-like proteins and their interactors in worm, fly, human and yeast. In order to increase the confidence in our predictions, we filtered the human-yeast common ING interactors to only those interactions conserved in fly (worm had poor homologs). We found 36 fly ING-interacting proteins with either yeast or human homologs, and only 5 showed conservation amongst the three species.

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