Table 7

Differentially expressed genes encoding kinases in artesunate-treated cells

Gene ID

Description

Kinase type

Name

ART 90 min

ART 3 h

HS

CQ


PFL0040c

protein kinase, R45/FIKK family

R45/FIKK

FIKK12

0,88

1,16

MAL7P1.144

protein kinase, R45/FIKK family

R45/FIKK

FIKK7.1

0,90

1,82

PFI0095c

protein kinase, R45/FIKK family

R45/FIKK

FIKK9.1

0,83

1,28

PF11_0510

protein kinase, R45/FIKK family

R45/FIKK

FIKK11

0,95

PFD1165w

protein kinase, R45/FIKK family

R45/FIKK

FIKK4.1

1,05

PFL1885c

calcium/calmodulin-dependent protein kinase 2, putative

kinase

PfPK2

1,35

1,21

PFL2280w

cyclin g-associated kinase, putative

kinase

1,10

PF14_0346

cGMP-dependent protein kinase 1, beta isozyme, putative

kinase

1,03

PF11_0242

protein kinase

kinase

0,95

PF14_0294

mitogen-activated protein kinase 1, PfMAP1

kinase

PfMAP1

1,05

PFD0975w

ROI kinase-like protein

RIO1

0,90

+

PF11_0377

casein kinase 1, PfCK1

kinase

-0,91

+

PF11_0227

serine/threonine protein kinase, puative

kinase

-0,98

PFB0150c

protein kinase, putative

kinase

-1,05


Gene ID: identifier as found in PlasmoDB.

Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.

CQ column: over (+) or under (-) expression.

Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].

Kinases were defined as genes fitting the HMM profil kinase PF00069 (update of Ward et al. [39]) and ROI Kinases as genes fiiting the HMM profil PF01163. FIKK kinases were defined as described in Schneider and Puijalon [41].

Natalang et al. BMC Genomics 2008 9:388   doi:10.1186/1471-2164-9-388

Open Data