Table 2 |
||||
|
Validation of the microarray data from crocidolite-treated human A549 cells |
||||
|
Gene |
Alias for Protein Product |
Affymetrix* (fold change) this study |
QRT-PCR (fold change) this study |
Changes in mRNA levels in human cells observed by other groups |
|
|
||||
|
EGR1 |
Egr1 |
115.7 |
281.7 ± 3.8 |
|
|
ATF3 |
ATF3 |
25.3 |
23.7 ± 0.1 |
|
|
c-Jun |
c-Jun |
8.6 |
10.5 ± 0.7 |
|
|
JunB |
JunB |
2.2 |
3.6 ± 0.2 |
|
|
IL8 |
Interleukin 8 |
16.6 |
N.D. |
Increased [73] |
|
TP53 |
p53 |
1.8 |
N.D. |
|
|
SOD2 |
Mn-SOD |
2.2 |
N.D. |
Increased [75]‡ |
|
HMOX1 |
Heme oxygenase 1 |
2.1 |
N.D. |
|
|
c-myc |
myc |
2.0 |
N.D. |
Increased [77] |
|
CDKN1A |
p21, Cip1 |
1.9 |
N.D. |
|
|
|
||||
|
*represents significantly greater than control, q less than 0.05; N.D., not determined † chrysotile-treated A549 human lung epithelial cells ‡ crocidolite-treated human pleural mesothelial cells |
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|
Hevel et al. BMC Genomics 2008 9:376 doi:10.1186/1471-2164-9-376 |
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