 Research articleNovel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functionsJoan M Hevel1,2 1 Department of Chemistry and Biochemistry, Utah State University, Logan, USA 2 Center for Integrated BioSystems, Utah State University, Logan, USA 3 Department of Mathematics and Statistics, Utah State University, Logan, USA
BMC Genomics 2008, 9:376doi:10.1186/1471-2164-9-376
Additional filesAdditional File 1: Low variability in the dataset. A comparison of the RMA expression values for the 54,675 probe sets on each of the six arrays. The tighter relationships within the Control and Treated groups are indicative of a data set with low variability. This low variability allowed the identification of a large number (2,546) of statistically significantly differentially expressed genes. Format: PDF Size: 26KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 2: List of genes for which expression was increased or decreased two-fold or greater. Format: XLS Size: 89KB Download file This file can be viewed with: Microsoft Excel Viewer Additional File 3: Global test to identify specific gene ontologies related to DNA repair and damage. A global test (Goeman et al., 2004; Goeman et al., 2005; Goeman and Oosting 2007) was used to identify specific gene ontologies related to DNA repair and damage. The p-values for each of the GO terms (abbreviated as the last four digits of each ontology's identifier) has been overlaid onto the hierarchical tree where the darkest blue node represents a p = 0.15 and the lightest represents a p = 0.016. Format: PDF Size: 438KB Download file This file can be viewed with: Adobe Acrobat Reader |
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