|
Gene symbol, description, and overall % mRNA abundance among genes investigated |
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| FA import into cells |
% RNA1 |
Triacylglycerol synthesis |
% RNA |
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|
|
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| LPL |
Lipoprotein lipase |
9.56 |
GPAM |
Glycerol-3-phosphate acyltransferase, mitochondrial |
2.31 |
| CD36 |
CD36 molecule (thrombospondin receptor) |
4.66 |
AGPAT6 |
1-acylglycerol-3-phosphate O-acyltransferase 6 |
1.28 |
| VLDLR |
Very-Low Density Lipoprotein Receptor |
0.09 |
DGAT1 |
Diacylglycerol acyltransferase 1 |
0.14 |
| Xenobiotic and Cholesterol transport |
DGAT2 |
Diacylglycerol acyltransferase 2 |
<0.01 |
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| ABCA1 |
ATP-binding cassette, sub-family A (ABC1), member 1 |
0.07 |
LPIN1 |
Lipin 1 |
0.13 |
| ABCG2 |
ATP-binding cassette, sub-family G (WHITE), member 2 |
8.54 |
Regulation of transcription |
||
| Acetate and FA activation and intra-cellular transport |
INSIG1 |
Insulin induced gene 1 |
0.35 |
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| ACSS1 |
acyl-CoA synthetase short-chain family member 1 |
0.33 |
INSIG2 |
Insulin induced gene 2 |
0.09 |
| ACSS2 |
acyl-CoA synthetase short-chain family member 2 |
0.59 |
SCAP |
SREBP cleavage activating protein |
0.13 |
| ACSL1 |
Acyl-CoA synthetase long-chain family member 1 |
0.89 |
SREBF1 |
Sterol regulatory element-binding transcription factor 1 |
0.15 |
| ACBP |
Acyl-CoA binding protein (diazepam binding inhibitor) |
0.17 |
SREBF2 |
Sterol regulatory element-binding transcription factor 2 |
0.10 |
| FABP3 |
Fatty acid-binding protein, heart |
15.49 |
THRSP |
Thyroid hormone responsive SPOT14 |
0.01 |
| Fatty acid synthesis and desaturation |
PPARG |
Peroxisome proliferator-activated receptor gamma |
0.01 |
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| ACACA |
Acetyl-coenzyme A carboxylase alpha |
0.91 |
PPARGC1A |
PPAR gamma, coactivator 1 alpha |
0.04 |
| FADS1 |
Fatty acid desaturase 1 (delta-5 desaturase) |
0.20 |
PPARGC1B |
PPAR gamma, coactivator 1 beta |
0.01 |
| FADS2 |
Fatty acid desaturase 2 (delta-6 desaturase) |
<0.01 |
Sphingolipid synthesis |
||
| FASN |
Fatty acid synthase |
7.05 |
SPTLC1 |
Serine palmitoyltransferase, long chain base subunit 1 |
0.15 |
| SCD |
Stearoyl-CoA desaturase (delta-9-desaturase) |
23.14 |
SPTLC2 |
Serine palmitoyltransferase, long chain base subunit 2 |
0.15 |
| Lipid droplet formation |
LASS2 |
LAG1 homolog, ceramide synthase 2 |
0.61 |
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| ADFP |
Adipose differentiation related protein (adipophilin) |
9.56 |
SPHK2 |
Sphingosine kinase 2 |
0.09 |
| BTN1A1 |
Butyrophilin, subfamily 1, member A1 |
4.78 |
ASAHL |
N-acylsphingosine amidohydrolase-like |
0.05 |
| XDH |
Xanthine dehydrogenase |
7.39 |
SGPL1 |
Sphingosine-1-phosphate lyase |
0.06 |
| PLIN |
Perilipin |
0.01 |
UGCG |
Ceramide glucosyltransferase |
0.18 |
| Ketone body utilization |
OSBP |
Oxysterol-binding protein 1 |
0.12 |
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| BDH1 |
3-hydroxybutyrate dehydrogenase, type 1 |
0.02 |
OSBPL2 |
Oxysterol binding protein-like 2 |
0.17 |
| OXCT1 |
3-oxoacid CoA transferase 1 |
0.07 |
OSBPL10 |
Oxysterol binding protein-like 10 |
0.06 |
|
1 The % mRNA abundance is calculated by [((1/EΔCt) specific gene/sum (1/EΔCt) all genes) × 100]. See Materials and Methods for details | |||||
Bionaz and Loor BMC Genomics 2008 9:366 doi:10.1186/1471-2164-9-366 |
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