Table 1

Gene ontology enrichment

FPD

CBF

E8.5

E12


GO: Biological processes

Immune response p = 6.5 × 10-5 36 genes

Macromolecular complex assembly p = 0.02 47 genes

Blood vessel development p = 0.06 15 genes

Response to external stimulus* p = 0.0003 18 genes

Negative regulation of apoptosis p = 0.002 16 genes

Cell growth p = 0.02 21 genes

Behavior p = 0.0003 14 genes

Response to biotic stimulus p = 0.002 19 genes

Immune system process p = 0.0006 18 genes

Cell proliferation p = 0.01 36 genes


GO: Molecular functions

Cadmium ion binding p = 0.002 4 genes

RNA binding p = 0.03 50 genes

IgG binding p = 0.006 3 genes

Cadmium ion binding p = 0.03 4 genes

Ferric-chelate reductase activity p = 0.03 2 genes

Polysaccharide binding p = 0.03 6 genes


GO: cellular component

Spindle p = 0.06 11 genes

Cell junction p = 0.06 14 genes

Cell surface p = 0.05 9 genes

Extracellular space p = 0.06 37 genes


InterPro motifs (FatiGo)

Vertebrate metallothionein p = 0.0001

Vertebrate metallothionein p = 0.02

Tubulin p = 0.04


The most significant gene ontology annotations are indicated for each dataset as identified through GOStat in April 2007. InterPro motifs were identified through the FatiGo program. The p-values are corrected for multiple testing (False discovery rate, Benjamini).

Michaud et al. BMC Genomics 2008 9:363   doi:10.1186/1471-2164-9-363

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