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Open AccessHighly AccessResearch article

Integrative analysis of RUNX1 downstream pathways and target genes

Joëlle Michaud1,2,9 email, Ken M Simpson3 email, Robert Escher1,10 email, Karine Buchet-Poyau4,11,12 email, Tim Beissbarth3,13 email, Catherine Carmichael1,2 email, Matthew E Ritchie3 email, Frédéric Schütz2,3 email, Ping Cannon1 email, Marjorie Liu5 email, Xiaofeng Shen6 email, Yoshiaki Ito7 email, Wendy H Raskind8 email, Marshall S Horwitz8 email, Motomi Osato7 email, David R Turner6 email, Terence P Speed3 email, Maria Kavallaris5 email, Gordon K Smyth3 email and Hamish S Scott1,14,15 email

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia

Department of Medical Biology, The University of Melbourne, 3050 Parkville, Victoria, Australia

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia

Division of Medical Genetics, University of Geneva Medical School, 1211 Geneva, Switzerland

Experimental Therapeutics Program, Children's Cancer Institute Australia for Medical Research, 2031 NSW, Australia

Department of Hematology and Genetic Pathology, School of Medicine, Flinders University, 5001 South Australia, Australia

Molecular and Cell Biology, National University of Singapore, 117543 Singapore

Division of Medical Genetics, University of Washington, Seattle, USA

Center for Integrative Genomics, University of Lausanne, Switzerland

10  Internal Medicine, University Hospital, Berne, Switzerland

11  Université de Lyon, Lyon, F-69008, France; Université Lyon 1, Domaine Rockfeller, Lyon, F-69008, France

12  CNRS UMR 5201, Laboratoire de Génétique Moléculaire, Signalisation et Cancer, Lyon, F-69008, France

13  Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

14  Division of Molecular Pathology, the Institute of Medical and Veterinary Science and The Hanson Institute, Box 14 Rundle Mall Post Office, Adelaide, SA 5000, Australia

15  The School of Medicine the University of Adelaide, SA, 5005, Australia

author email corresponding author email

BMC Genomics 2008, 9:363doi:10.1186/1471-2164-9-363

Published: 31 July 2008

Additional files

Additional File 1:

Additional Methods, Figures S1 to S4 and Tables S3 to S6. Additional figures and tables to support the statistical and bioinformatics analyses described in the manuscript.

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Additional File 2:

Table S1. Gene expression profiling results. Summary of the gene expression profiling results, oPOSSUM and corresponding mouse Affymetrix data for each clone Accession number present on the human cDNA array.

Format: TXT Size: 1.8MB Download file

Additional File 3:

Table S2. Gene expression profiling data for E8.5 and E12 Runx1 knockout embryos.

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Additional File 4:

Figure S4. Supporting graphs for the Gene Set Enrichment analysis.

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Additional File 5:

Figure S5. Expression pattern of RUNX1 and a subset of differentially expressed genes.

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