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Open Access Correspondence

Comparative phylogenomic analyses of teleost fish Hox gene clusters: lessons from the cichlid fish Astatotilapia burtoni: comment

Morgane Thomas-Chollier123* and Valérie Ledent1

Author Affiliations

1 Belgian EMBnet Node, Université Libre de Bruxelles – CP 257, Bd du Triomphe, B-1050 Brussels, Belgium

2 Genomes and Networks Bioinformatics, Université Libre de Bruxelles – CP 263, Bd du Triomphe, B-1050 Brussels, Belgium

3 Laboratory for Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium

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BMC Genomics 2008, 9:35  doi:10.1186/1471-2164-9-35

Published: 24 January 2008

Abstract

A reanalysis of the sequences reported by Hoegg et al has highlighted the presence of a putative HoxC1a gene in Astatotilapia burtoni. We discuss the evolutionary history of the HoxC1a gene in the teleost fish lineages and suggest that HoxC1a gene was lost twice independently in the Neoteleosts. This comment points out that combining several gene-finding methods and a Hox-dedicated program can improve the identification of Hox genes.