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Genes responsive to PI3K, mTOR and p70S6K inhibitions in breast cancer cell lines. |
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| BT-474 breast cancer cell line, RPS6KB1-suppressed |
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| Gene Name |
Description |
Inhibitor |
Expression |
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| ARL11 |
ADP-ribosylation factor-like 11 |
Ly294002 |
U |
| B2M |
beta-2-microglobulin |
Ly294002 |
U |
| CECR1 |
cat eye syndrome chromosome region, candidate 1, transcript variant 1 |
Ly294002 |
U |
| PCDH10 |
protocadherin 10, transcript variant 1 |
Ly294002 |
U |
| PCDH11Y |
protocadherin 11 Y-linked, transcript variant c |
Ly294002 |
U |
| PPP1R12B |
protein phosphatase 1, regulatory (inhibitor) subunit 12B, transcript variant 3 |
Ly294002 |
U |
| PSORS1C1 |
psoriasis susceptibility 1 candidate 1 |
Ly294002 |
U |
| ST3GAL6 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
Ly294002 rapamycin |
U |
| CDKN2B |
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), transcript variant 1 |
rapamycin |
U |
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| MCF-7 breast cancer cell line, RPS6KB1-suppressed |
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| Gene Name |
Description |
Inhibitor |
Expression |
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| COL5A1 |
collagen, type V, alpha 1 |
Ly294002 |
U |
| FAM5C |
family with sequence similarity 5, member C |
Ly294002 |
U |
| RELB |
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) |
Ly294002 |
U |
| SOX15 |
SRY (sex determining region Y)-box 15 |
Ly294002 |
U |
| ST3GAL6 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
Ly294002 |
U |
| VTCN1 |
V-set domain containing T cell activation inhibitor 1 |
Ly294002 |
D |
| IFI44L |
interferon-induced protein 44-like |
rapamycin |
D |
| OASL |
2'-5'-oligoadenylate synthetase-like, transcript variant 1 |
rapamycin |
D |
| SCD |
stearoyl-CoA desaturase (delta-9-desaturase) |
rapamycin |
D |
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The genes were differentially expressed to the same direction by small molecule inhibitors and at least two RPS6KB1 siRNAs. Abbreviations: D = downregulated expression, U = upregulated expression. | |||
Heinonen et al. BMC Genomics 2008 9:348 doi:10.1186/1471-2164-9-348 |
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