Topoisomerase II inhibition involves characteristic chromosomal expression patterns

doi:10.1186/1471-2164-9-324

BMC Genomics

Volume 9

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Research article

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

Susanne Reymann¹ and Jürgen Borlak¹^,2

¹Fraunhofer Institute of Toxicology and Experimental Medicine (Fh-ITEM), Center for Drug Research and Medical Biotechnology, Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany

²Center of Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany

author email corresponding author email

BMC Genomics 2008, 9:324doi:10.1186/1471-2164-9-324


Published:	8 July 2008

Additional files

Additional File 1:

Lists of genes significantly deregulated after treatment with Aroclor1254, trovafloxacin, doxorubicin, etoposide and after overexpression of c-myc. Exclusively genes possessing a RefSeq accession number were listed. The regulated genes whose TSSs are located within 100 kbp and their corresponding expression values are marked yellow. The file clearly shows that these gene pairs do not show similar expression levels. In many cases transcriptionally induced as well as transcriptionally repressed genes occur within 100 kbp.

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