Allele-specific splicing evidence in the GLO1 based on exon array analysis. Support for allele-specific exon-skipping in the GLO1 gene. (A) Genomic sequence of the GLO1 gene showing the alternatively spliced exons. The boxed section is magnified and drawn to scale in the next panel. (B) Illustration of the relationship between the genotypes of this SNP and splicing indices of nearby probesets, using the same conventions as in Figure 3. (C) Histograms showing the splicing index distribution as a function of the genotype of a SNP, rs2736654, predicted to affect an exonic splice enhancer site. (D) Association plot illustrating that rs2736654 is marginally more strongly associated with a probeset spanning exon 4 than any of the other SNPs in the region for which genotype data were available.
Nembaware et al. BMC Genomics 2008 9:265 doi:10.1186/1471-2164-9-265