Principal component analysis of 361 differentially expressed bronchial epithelial genes across bronchial, nasal, and buccal mucosa samples. PCA of the expression of genes that are perturbed by smoking in the bronchial airway in samples of bronchial, nasal, and buccal epithelium from smokers and non-smokers. Bronchial and nasal epithelial samples separate according to smoking status, while the separation of buccal mucosa samples by smoking status is less pronounced. The first two principal components account for 27% and 9% of the total variance in gene expression respectively.
Sridhar et al. BMC Genomics 2008 9:259 doi:10.1186/1471-2164-9-259