Figure 9.

Analysis of BMP signaling processes in ERK1MO and ERK2MO gene expression profiles. The BMP signaling pathways has been overlaid with gene-expression colour criterion and ratios of gene-expression from the program GenMAPP: yellow = up-regulated by ERK1MO (ratio > 1), blue = down-regulated by ERK1MO (ratio <1), red = up-regulated by ERK2MO (ratio > 1), green = down-regulated by ERK2MO (ratio <1), gray = gene is not present on the Agilent zebrafish 22k microarrays or in the GenMAPP database, white = not significantly changed. The genes that were affected in their expression in both ERK1 and ERK2 morphants show multicolored gene-boxes with the expression ratios for both conditions depicted on the right of the gene; the ration for ERK1 knockdown at the top and ERK2 knockdown below. At the right side of the figure a list of responsive target-genes is listed for the BMP signaling pathway. The bottom right of the figure shows a small representation of the predicted BMP signaling activity (dark gray) in the wild type embryos, based on the potential range of signals and the expression patterns and range of antagonists adopted from Schier and Talbot (2005), late blastula stage, lateral view, dorsal to right and animal pole to top.