Non-random retention of protein-coding overlapping genes in Metazoa

doi:10.1186/1471-2164-9-174

BMC Genomics

Volume 9

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Soldà G
Suyama M
Pelucchi P
Boi S
Guffanti A
Rizzi E
Bork P
Tenchini ML
Ciccarelli FD

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Soldà G
Suyama M
Pelucchi P
Boi S
Guffanti A
Rizzi E
Bork P
Tenchini ML
Ciccarelli FD
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Research article

Non-random retention of protein-coding overlapping genes in Metazoa

Giulia Soldà¹^* , Mikita Suyama²^* , Paride Pelucchi³ , Silvia Boi¹ , Alessandro Guffanti³ , Ermanno Rizzi³ , Peer Bork⁴ , Maria Luisa Tenchini¹ and Francesca D Ciccarelli⁵^,6

¹Department of Biology and Genetics for Medical Sciences, University of Milan, 20133 Milan, Italy

²Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, 606-8501 Kyoto, Japan

³Institute of Biomedical Technologies, National Research Council, Via Fantoli 16/15, 20138 Milan, Italy

⁴European Molecular Biology Laboratory, Meyerhofstr.1, 69012 Heidelberg, Germany

⁵Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy

⁶FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy

author email corresponding author email* Contributed equally

BMC Genomics 2008, 9:174doi:10.1186/1471-2164-9-174


Published:	16 April 2008

Additional files

Additional file 1:

Features of the unique RefSeq genes used for the analysis.

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Additional file 2:

Datasets of overlapping gene clusters in five metazoan genomes. The file is formatted with one worksheet for each species analyzed. For each dataset the cluster number, the number of component and the list of RefSeq Accession numbers of all components are reported.

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Additional file 3:

Parallel overlaps conserved between human and mouse. We manually reviewed the main literature on the genes involved in parallel OGCs conserved between human and mouse to look for possible functional links. We signed as 'Not Known' the cases where either the transcripts correspond to not yet annotated genes, or no functional link can be derived from the available literature.

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Additional file 4:

Phylogenetic analysis of the OGC conserved between nematodes and vertebrates.

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Additional file 5:

Literature overview of human overlapping genes. The numbering for the literature references refers to Additional file 6.

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Additional file 6:

Additional bibliographic references. Document providing all the literature references cited in the Additional data files.

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