Table 1

Tissues sampled
Group	Tissue	Abbreviation	Embryonic origin	Function, remarks	Sampling details	# Extreme Probes^a	Principal KEGG pathways of extreme probes

Brain	Olfactory bulb	OLFB	Ectoderm (neural)	Perception of odors	Whole organ from both sides	274	Neuroactive ligand-receptor interaction WNT signalling pathway
	Hypothalamus	HYPT	Ectoderm (neural)	Regulates metabolic processes and other activities of the Autonomic Nervous System	Including mammilary body and grey tubercle	147	Neuroactive ligand-receptor interaction Cell adhesion molecules (CAMS)
	Pineal gland	PING	Ectoderm (neural)	Production of melatonin	Whole gland	89	-
	Adenohypophysis	AHYP	Ectoderm (stomodeum)	Hormone secretion regulating endocrine glands	Whole gland	241	Neuroactive ligand-receptor interaction
	Neurohypophysis	NHYP	Ectoderm (neural)	Store and liberation of hormones synthesized by the hypothalamus	Whole gland	130	WNT signalling pathway
Endocrine	Adrenal cortex	ADGC	Mesoderm	Synthesis of corticosteroid hormones	Part of the gland after mechanical separation	14	-
	Adrenal medulla	ADGM	Ectoderm (Neural crest)	Synthesis of adrenaline and noradrenalin	Part of the gland after mechanical separation	12	-
	Thyroid gland	THYG	Endoderm + Ectoderm (neural crest)	Production of thyroxine (T4), triiodothyronine (T3), and calcitonin	Part of the gland	376	-
Structural	Diaphragm muscle	DIAP	Mesoderm	Predominant oxidative metabolism	Samples from left and right crura	166	Oxidative phosphorylation ATP synthesis Glycolysis Citrate cycle Piruvate metabolism
	M. Biceps femoris	BIFE	Mesoderm	Glycolitic metabolism	Lateral area of the muscle	354	Glycolysis Insulin signalling pathway Frutose and manose metabolism Starch and sucrose metabolism Pentose phosphate pathway
	Back fat tissue	FATB	Mesoderm	Fat	Fat from lumbar region	51	-
	Abdominal fat tissue	FATA	Mesoderm	Fat	Fat external to the rectus sheath	21	-
Metabolic	Stomach	STOM	Endoderm	Digestion	Epithelium from the body	156	Tight junction
	Liver	LIVR	Endoderm	Central role in metabolism	Parts from quadrate and left lateral lobes	824	Urea cycle Bile acid biosynthesis Biosynthesis of steroids Complement and coagulation cascades Fatty acid metabolism Propanoate metabolism Amino acids metabolisms Butanoate metabolism Metabolism of xenobiotics by cytochrome P450
	Ileum	ILEU	Endoderm	Absorption of products of digestion	Epithelium	570	Cell cycle Ribosome Pyrimidine metabolism Antigen processing and presentation
	Blood	BLOO	Mesoderm	Supply of oxygen and nutrients	Blood from the femoral vein	3253	Hematopoietic cell lineage Regulation of actin cytoskeleton T-cell receptor signalling Focal adhesion ECM receptor interaction Cytokine cytokine receptor interaction Cell adhesion molecules (CAMS) MAPK signalling pathway JAK-STAT signalling pathway Tight junction

^aThe complete list is in Supplementary Table S2. See Material and Methods for definition of extreme probe.
Ferraz et al. BMC Genomics 2008 9:173 doi:10.1186/1471-2164-9-173