AT-bias at the A+/T+ boundary – comparison with two control genomes. The black line shows the actual mouse genome (11750 boundaries). a) The red line shows the shuffled genome (1017 boundaries) b) The blue line shows the hybrid genome (4124 boundaries), that is the genome has been shuffled and then the sequence for the genes has been restored at their original positions. The thickness of all lines show 95% confidence limits and all lines show moving averages over 100 bases. There is a statistically significant difference between the black and red lines and between the black and blue lines: one-tailed z-test at position 5000 bases downstream of the the boundary: a) p < 10-50 n1 = 11750, n2 = 1017, z = 21. b) p < 10-50 n1 = 11750, n2 = 4124, z = 20.
Evans BMC Genomics 2008 9:16 doi:10.1186/1471-2164-9-16