H-rule measure by position with respect to segment boundary. The black line (line with peak) gives the value of the H-rule measure with respect to the A+/T+ boundary, and the red line with respect to the T+/A+ boundary. The data from both sides of the boundary have been averaged. The thickness of both lines shows 95% confidence limits. The black line has a peak at the boundary but the red line does not. This suggests that the A+/T+ boundary is a region which binds to the nuclear proteins of the matrix, in particular, SATB1. a) Mouse: b) Human (genome assembly NCBI35). For both plots the difference between the lines at the boundary is statistically significant, two-tailed z-test: a) p < 10-50, n1 = 11750, n2 = 11753, z ~ 104: b) p < 10-50, n1 = 12375, n2 = 12369, z ~ 96.
Evans BMC Genomics 2008 9:16 doi:10.1186/1471-2164-9-16