Amino acid property variation in NADH dehydrogenase subunits ND2/3/5. Topological assignment of the sites that present a high number of radically changing properties under positive-destabilizing selection in three subunits of the NADH dehydrogenase complex that are suggested to be proton pumping devices. The transmembrane domain average prediction is shown in grey (for details see Material and Methods section). MM: mitochondria matrix; IM: intermembrane space.
da Fonseca et al. BMC Genomics 2008 9:119 doi:10.1186/1471-2164-9-119