Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

doi:10.1186/1471-2164-8-80

BMC Genomics

Volume 8

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Yuan M
Kendziorski CM
Weindruch R
Prolla TA

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Research article

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Michael G Edwards¹ , Rozalyn M Anderson² , Ming Yuan³ , Christina M Kendziorski⁴ , Richard Weindruch²^,5 and Tomas A Prolla¹

¹Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA

²Veterans Administration Hospital, University of Wisconsin, Madison, WI, USA

³School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA

⁴Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA

⁵Department of Medicine and Wisconsin Primate Research Center, University of Wisconsin, Madison, WI, USA

author email corresponding author email

BMC Genomics 2007, 8:80doi:10.1186/1471-2164-8-80


Published:	23 March 2007

Additional files

Additional file 1:

Transcripts with age effect in mouse gastrocnemius muscle. Table of transcripts, listed alphabetically, that increased or decreased significantly (PP > 0.90) with age in mouse gastrocnemius muscle.

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Additional file 2:

Expression of p53-related genes in wild type and transgenic GPX4 and MnSOD mice. Relative expression ratio ± SE for mRNA levels, as determined by RT-PCR, for p21, p16, Gadd45a and p53 in (a) 5 month old GPX+/+ and GPX+/- and (b) 9 month old SOD+/+ and SOD+/- gastrocnemius muscle (n = 5 for each group). Only the expression of p53 was considered significantly different (Student's T-Test; *P < 0.05) between GPX+/+ and GPX+/- mice.

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Additional file 3:

Expression of p53-mediated proapoptotic genes in wild type and transgenic GPX4 and MnSOD mice. Relative expression ratio ± SE for mRNA levels, as determined by RT-PCR, for Bbc3 (Puma), Pmaip1 (Noxa), Tnfrsf10b (Killer/Dr5) and Bok in (a) 5 month old GPX+/+ and GPX+/- and (b) 9 month old SOD+/+ and SOD+/- gastrocnemius muscle (n = 5 for each group). Only the expression of Tnfrsf10b was considered significantly different (Student's T-Test; *P < 0.05) between GPX+/+ and GPX+/- mice.

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