Research article
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
-
* Corresponding author: Tomas A Prolla taprolla@facstaff.wisc.edu
1 Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA
2 Veterans Administration Hospital, University of Wisconsin, Madison, WI, USA
3 School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA
4 Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA
5 Department of Medicine and Wisconsin Primate Research Center, University of Wisconsin, Madison, WI, USA
BMC Genomics 2007, 8:80 doi:10.1186/1471-2164-8-80
Published: 23 March 2007Additional files
Additional file 1:
Transcripts with age effect in mouse gastrocnemius muscle. Table of transcripts, listed alphabetically, that increased or decreased significantly (PP > 0.90) with age in mouse gastrocnemius muscle.
Format: PDF Size: 150KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
Expression of p53-related genes in wild type and transgenic GPX4 and MnSOD mice. Relative expression ratio ± SE for mRNA levels, as determined by RT-PCR, for p21, p16, Gadd45a and p53 in (a) 5 month old GPX+/+ and GPX+/- and (b) 9 month old SOD+/+ and SOD+/- gastrocnemius muscle (n = 5 for each group). Only the expression of p53 was considered significantly different (Student's T-Test; *P < 0.05) between GPX+/+ and GPX+/- mice.
Format: PDF Size: 12KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 3:
Expression of p53-mediated proapoptotic genes in wild type and transgenic GPX4 and MnSOD mice. Relative expression ratio ± SE for mRNA levels, as determined by RT-PCR, for Bbc3 (Puma), Pmaip1 (Noxa), Tnfrsf10b (Killer/Dr5) and Bok in (a) 5 month old GPX+/+ and GPX+/- and (b) 9 month old SOD+/+ and SOD+/- gastrocnemius muscle (n = 5 for each group). Only the expression of Tnfrsf10b was considered significantly different (Student's T-Test; *P < 0.05) between GPX+/+ and GPX+/- mice.
Format: PDF Size: 13KB Download file
This file can be viewed with: Adobe Acrobat Reader