Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines

Penny Nymark^*¹^,2 , Pamela M Lindholm^*² , Mikko V Korpela³ , Leo Lahti³ , Salla Ruosaari¹^,2^,3 , Samuel Kaski³ , Jaakko Hollmén³ , Sisko Anttila¹ , Vuokko L Kinnula⁴ and Sakari Knuutila²

¹Health and Work Ability, Biological Mechanisms and Prevention of Work-related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland

²Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

³Helsinki Institute for Information Technology, Laboratory of Computer and Information Science, Helsinki University of Technology, Espoo, Finland

⁴Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

author email corresponding author email* Contributed equally

BMC Genomics 2007, 8:62doi:10.1186/1471-2164-8-62


Published:	1 March 2007

Additional files

Additional File 1:

GO analysis. The file contains enriched biological processes in each time point and each cell line.

Format: XLS Size: 91KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional File 2:

A549 clusters. The file contains profiles from all significant clusters in cell line A549. The X-axis shows the time points from 0h-7 days) and the Y-axis shows an expression ratio profile that is representative of all probe sets in the cluster. Due to the correlation based distance measure used in the clustering method (Ernst et al, 2005), the scale of the Y-axis is not significant.

Format: EPS Size: 611KB Download file

Additional File 3:

Beas-2B clusters. The file contains profiles from all significant clusters in cell line Beas-2B. The X-axis shows the time points from 0h-48h and the Y-axis shows an expression ratio profile that is representative of all probe sets in the cluster. Due to the correlation based distance measure used in the clustering method (Ernst et al, 2005), the scale of the Y-axis is not significant.

Format: EPS Size: 813KB Download file

Additional File 4:

Cluster analysis. The file contains lists of all genes included in all significant clusters of each cell line.

Format: XLS Size: 6.8MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional File 5:

Canonical correlation analysis. The file contains list of genes contributing to the enrichment of the chromosomal regions that contribute to the common correlation between the cell lines A549 and Beas-2B.

Format: XLS Size: 117KB Download file

This file can be viewed with: Microsoft Excel Viewer