Figure 1.

Genes involved in lipids biosynthesis and clearance pathways were altered in type II cells from Stat3^Δ/Δ mice. A. Srebf1 and Srebf2 regulate genes encoding the major metabolic enzymes in the fatty acid, cholesterol and phospholipids biosynthesis. The arrow (↑) indicates that the mRNA level was induced in Stat3^Δ/Δ mice; (↓) indicates the mRNA level was reduced in Stat3^Δ/Δ mice. Gene symbols, descriptions and the expression changes are listed in panel B.