Table 2 |
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|
Microarrays results |
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|
Gene name |
Symbol |
Fold change BBP/Control |
Gene ID |
|
|
|||
|
21 days |
|||
|
Up-regulated genes |
|||
|
Morphogenesis, organogenesis and cell differentiation |
|||
|
Cadherin 1 |
Cdh1 |
2.21 |
|
|
Cadherin EGF LAG seven-pass G-type receptor 3 |
Celsr3 |
2.16 |
|
|
Cardiotrophin 1 |
Ctf1 |
1.98 |
|
|
Early growth response 2 |
Egr2 |
2.03 |
|
|
Endothelial cell-specific molecule 1 |
Esm1 |
1.91 |
|
|
Forkhead box G1 |
Foxg1 |
2.21 |
|
|
Gamma-aminobutyric acid (GABA) B receptor 1 |
Gabbr1 |
2.14 |
|
|
Glutamate receptor, metabotropic 5 |
Grm5 |
2.52 |
|
|
Glypican 2 (cerebroglycan) |
Gpc2 |
1.83 |
|
|
NAD(P)H dehydrogenase, quinone 2 |
Nqo2 |
1.94 |
|
|
Odd Oz/ten-m homolog 2 (Drosophila) |
Odz2 |
2.15 |
|
|
Parathyroid hormone-like peptide |
Pthlh |
2.03 |
|
|
Pregnancy-induced growth inhibitor |
Okl38 |
2.29 |
|
|
RAS-like family 11 member B |
Rasl11b |
1.96 |
|
|
Tenascin R |
Tnr |
1.93 |
|
|
Wilms tumor 1 |
Wt1 |
2.77 |
|
|
Other transcription factors |
|||
|
CUG triplet repeat, RNA-binding protein 2 |
Cugbp2 |
2.00 |
|
|
Forkhead box A1 (Hnf3a) |
Foxa1 |
2.24 |
|
|
HNF-3/forkhead homolog-1 (Hfh1) |
Hfh1 |
2.08 |
|
|
Jun dimerization protein 2 |
Jundp2 |
2.05 |
|
|
Nuclear transcription factor-Y gamma |
Nfyc |
2.26 |
|
|
TEA domain family member 2 |
Tead2 |
1.87 |
|
|
Transcription elongation factor A (SII), 2 |
Tcea2 |
1.99 |
|
|
Transcription factor 2 |
Tcf2 |
2.04 |
|
|
Transcription factor 4 |
Tcf4 |
2.13 |
|
|
Cell proliferation |
|||
|
Alpha-2-glycoprotein 1, zinc |
Azgp1 |
2.08 |
|
|
Calcium/calmodulin-dependent protein kinase II beta subunit |
Camk2b |
1.83 |
|
|
Chemokine (C-X-C motif) ligand 10 |
Cxcl10 |
1.84 |
|
|
Insulin receptor substrate 2 |
Irs2 |
2.28 |
|
|
Neutrophil cytosolic factor 1 |
Ncf1 |
2.64 |
|
|
Platelet-derived growth factor, C polypeptide |
Pdgfc |
1.94 |
|
|
Upregulated by 1,25-dihydroxyvitamin D-3 |
Txnip |
2.58 |
|
|
Response to stress |
|||
|
Aryl hydrocarbon receptor |
Ahr |
1.95 |
|
|
Chemokine (C-C motif) ligand 5 |
Ccl5 |
2.05 |
|
|
Fc receptor, IgE, low affinity II, alpha polypeptide |
Fcer2a |
1.94 |
|
|
Heat shock 27 kD protein family, member 7 |
Hspb7 |
2.20 |
|
|
Heat shock factor 2 |
Hsf2 |
2.43 |
|
|
Myeloid cell leukemia sequence 1 |
Mcl1 |
1.84 |
|
|
Nitric oxide synthase 2, inducible |
Nos2 |
1.83 |
|
|
Oxidized low density lipoprotein (lectin-like) receptor 1 |
Oldlr1 |
2.09 |
|
|
Peptidoglycan recognition protein 1 |
Pglyrp1 |
1.99 |
|
|
Thioredoxin reductase 1 |
Txnrd1 |
2.24 |
|
|
Signal transduction |
|||
|
5-hydroxytryptamine (serotonin) receptor 2A |
Htr2a |
1.96 |
|
|
Activin receptor interacting protein 1 |
Acvrip1 |
2.24 |
|
|
Agouti |
A |
2.18 |
|
|
Angiotensin receptor-like 1 |
Agtrl1 |
2.06 |
|
|
Growth factor receptor bound protein 2-associated protein 2 |
Gab2 |
1.92 |
|
|
Growth hormone releasing hormone |
Ghrh |
1.98 |
|
|
Guanylate cyclase 1, soluble, beta 2 |
Gucy1b2 |
1.91 |
|
|
MAS-related G-protein coupled receptor, member G |
Mrgprg |
2.80 |
|
|
Mcf.2 transforming sequence-like |
Mcf2l |
2.24 |
|
|
Membrane-spanning 4-domains, subfamily A, member 2 |
Ms4a2 |
1.88 |
|
|
Protein kinase, cAMP-dependent, regulatory, type 2, alpha |
Prkar2a |
2.01 |
|
|
Rho guanine nucleotide exchange factor (GEF) 1 |
Arhgef1 |
2.09 |
|
|
Rho guanine nucleotide exchange factor 7 |
Arhgef7 |
1.88 |
|
|
Cell-cell signaling |
|||
|
4-aminobutyrate aminotransferase |
Abat |
1.85 |
|
|
Discs, large (Drosophila) homolog-associated protein 2 |
Dlgap2 |
2.38 |
|
|
Gap junction membrane channel protein beta 5 |
Gjb5 |
1.89 |
|
|
Metabolism |
|||
|
11-beta-hydroxysteroid dehydrogenase |
11-HSDIB |
1.93 |
|
|
Acetyl-coenzyme A carboxylase alpha |
Acaca |
2.09 |
|
|
Aldehyde oxidase 1 |
Aox1 |
2.39 |
|
|
Alpha 1,2-fucosyltransferase C gene |
Ftc |
1.98 |
|
|
Apolipoprotein A-I |
Apoa1 |
2.50 |
|
|
Cholinergic receptor, muscarinic 3 |
Chrm3 |
2.08 |
|
|
Diazepam binding inhibitor-like 5 |
Dbil5 |
1.84 |
|
|
Elastase 2 |
Ela2 |
2.03 |
|
|
Fatty acid binding protein 3 |
Fabp3 |
2.14 |
|
|
FK506 binding protein 1b |
Fkbp1b |
2.01 |
|
|
Glucosidase, alpha; acid (glycogen storage disease type II) |
Gaa |
2.30 |
|
|
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
Hsd3b1 |
1.94 |
|
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 |
Ndufa5 |
2.03 |
|
|
Nicotinamide nucleotide transhydrogenase |
Nnt |
1.95 |
|
|
Peptide/histidine transporter PHT2 |
Slc15a3 |
1.92 |
|
|
Phosphate cytidylyltransferase 1, choline, alpha isoform |
Pcyt1a |
2.49 |
|
|
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
Plod1 |
2.43 |
|
|
Proteasome (prosome, macropain) 26S subunit, ATPase 3 |
Psmc3 |
1.90 |
|
|
Protein kinase C, gamma |
Prkcc |
2.04 |
|
|
Serine/threonine kinase 2 |
Slk |
1.89 |
|
|
Small glutamine rich protein with tetratricopeptide repeats 2 |
Sgtb |
2.03 |
|
|
Succinate-semialdehyde dehydrogenase |
1.93 |
||
|
Transmembrane protease, serine 8 (intestinal) |
Tmprss8 |
1.88 |
|
|
Valosin-containing protein |
Vcp |
2.44 |
|
|
Transport |
|||
|
Adducin 1 (alpha) |
Add1 |
2.65 |
|
|
Apolipoprotein A-V |
Apoa5 |
2.00 |
|
|
Cholinergic receptor, nicotinic, alpha polypept. 1 |
Chrna1 |
1.88 |
|
|
CUB and zona pellucida-like domains 1 |
Cuzd1 |
2.25 |
|
|
Epidermal growth factor |
Egf |
2.05 |
|
|
Gamma-aminobutyric acid A receptor, gamma 2 |
Gabrg2 |
1.87 |
|
|
Glutamate receptor, ionotropic, kainate 4 |
Grik4 |
2.00 |
|
|
Glutamate receptor, ionotropic, NMDA2D |
Grin2d |
1.91 |
|
|
Olfactory receptor 226 |
Olfr41 |
1.90 |
|
|
Potassium inwardly-rectifying channel, subfamily J, member 6 |
Kcnj6 |
1.84 |
|
|
RAB10, member RAS oncogene family |
Rab10 |
2.33 |
|
|
Rabaptin, RAB GTPase binding effector protein 2 |
Rabep2 |
2.07 |
|
|
Sodium channel, voltage-gated, type II, beta polypeptide |
Scn2b |
2.01 |
|
|
Solute carrier family 12, member 4 |
Slc12a4 |
2.38 |
|
|
Solute carrier family 13, member 1 |
Slc13a1 |
1.89 |
|
|
Synaptotagmin 8 |
Syt8 |
2.48 |
|
|
Cell organization |
|||
|
Adaptor-related protein complex 3, mu 2 subunit |
Ap3m2 |
2.00 |
|
|
ATP-dependent, RNA helicase |
Ddx52 |
1.84 |
|
|
Bassoon |
Bsn |
1.94 |
|
|
Cadherin-8 |
Cdh8 |
2.42 |
|
|
Integrin alpha 5 |
Itga5 |
1.94 |
|
|
Myoglobin |
Mb |
2.13 |
|
|
Synaptotagmin 1 |
Syt1 |
2.14 |
|
|
Trans-golgi network protein 1 |
Tgoln2 |
1.93 |
|
|
Other |
|||
|
Alpha-1-B glycoprotein |
A1bg |
1.84 |
|
|
Aortic preferentially expressed gene 1 |
Apeg1 |
2.53 |
|
|
Arfaptin 1 |
LOC60382 |
2.00 |
|
|
CDC91 cell division cycle 91-like 1 (S.cerevisiae) |
Cdc91l1 |
2.57 |
|
|
Delta-like 1 homolog (Drosophila) |
Dlk1 |
2.30 |
|
|
Glycoprotein, synaptic 2 |
Gpsn2 |
1.87 |
|
|
Guanylate cyclase activator 2A |
Guca2a |
2.43 |
|
|
Heparan sulfate proteoglycan, perlecan domain I |
Cd44 |
2.20 |
|
|
Heat-responsive protein 12 |
Hrsp12 |
1.92 |
|
|
Insulin-like 6 |
Insl6 |
1.95 |
|
|
Kinesin-related protein KRP5 |
KRP5 |
1.99 |
|
|
Luteinizing hormone beta |
Lhb |
1.99 |
|
|
Ly6-C antigen |
Ly6c |
2.02 |
|
|
Mitochondrial capsule selenoprotein |
Mcsp |
2.46 |
|
|
Neural visinin-like Ca2+-binding protein type 2 |
Nvjp2 |
1.95 |
|
|
NIMA related kinase 2 |
Nek2 |
1.86 |
|
|
Nuclear GTPase PIKE |
PIKE |
1.84 |
|
|
Nucleoporin 98 |
Nup98 |
2.18 |
|
|
Oxytocin receptor |
Oxtr |
2.11 |
|
|
Olfactory-specific cytochrome P-450 |
P-450olf1 |
2.03 |
|
|
Potassium channel tetramerisation domain containing 13 |
Kctd13 |
2.33 |
|
|
Proline-rich protein 15 |
Prp15 |
2.24 |
|
|
RAB8A, member RAS oncogene family |
Mel |
2.12 |
|
|
Regucalcin gene promotor region related protein |
Rgpr |
2.05 |
|
|
Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
Rnasel |
2.05 |
|
|
Ring finger protein 38 |
Oip1 |
1.85 |
|
|
Serine protease inhibitor |
Spin2b |
2.67 |
|
|
Signal recognition particle 54 kDa |
Srp54 |
1.97 |
|
|
Sodium-cotransporter rkST1 |
rkST1 |
1.95 |
|
|
Synaptosomal-associated protein, 91 kDa homolog (mouse) |
Snap91 |
2.23 |
|
|
Telomerase catalytic subunit |
2.61 |
||
|
Titin |
Ttn |
1.88 |
|
|
Ubiquitin specific protease 11 |
Usp11 |
2.51 |
|
|
Zinc finger protein 14 (DZF14) |
DZF14 |
1.87 |
|
|
Zinc finger, DHHC domain containing 7 |
Zdhhc7 |
1.83 |
|
|
Down-regulated genes |
|||
|
Glutamate decarboxylase 1 |
Gad1 |
-3.65 |
|
|
35 days |
|||
|
Glutamate decarboxylase 1 |
Gad1 |
-2.69 |
|
|
50 days |
|||
|
Up-regulated genes |
|||
|
Carboxylesterase 1 |
Ces1 |
1.79 |
|
|
Carboxypeptidase A1 (pancreatic) |
Cpa1 |
1.74 |
|
|
Corticotropin releasing hormone 1 |
Crhr1 |
1.79 |
|
|
Ectonucleotide pyrophosphatase/phosphodiesterase 5 |
Enpp5 |
2.00 |
|
|
Glucagon receptor, transcript variant 2 |
Gcgr |
1.74 |
|
|
Glycoprotein 2 (zymogen granule membrane) |
Gp2 |
1.80 |
|
|
Malic enzyme 1 |
Me1 |
1.74 |
|
|
Nuclear receptor subfamily 4, group A, member 1 |
Nr4a1 |
2.06 |
|
|
Transcription elongation factor A2 |
Tcea2 |
1.75 |
|
|
Tryptophan hydroxylase |
Tph |
1.93 |
|
|
Down-regulated genes |
|||
|
Actinin alpha 3 |
Actn3 |
-2.76 |
|
|
Creatine kinase, muscle form |
Ckm |
-3.64 |
|
|
Glutamate decarboxylase 1 |
Gad1 |
-2.69 |
|
|
Myosin, light polypeptide 2 |
Myl2 |
-4.90 |
|
|
Parvalbumin (calcium binding protein) |
Pvalb |
-2.38 |
|
|
Titin |
Ttn |
-2.51 |
|
|
Troponin I, skeletal, fast 2 |
Tnni2 |
-2.46 |
|
|
Troponin-c |
Tnnc2 |
-4.77 |
|
|
|
|||
|
100 days |
|||
|
|
|||
|
Translin |
Tsn |
2.40 |
|
|
Whey acidic protein |
Wap |
2.87 |
|
|
|
|||
|
List of known genes down- and up-regulated in mammary glands of BBP treated rats at 21, 35, 50 and 100 days. Average fold change related to control mammary glands is indicated. Up-regulated genes at 21 days have been sorted by function according to level 4 of Gene Ontology. |
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|
Moral et al. BMC Genomics 2007 8:453 doi:10.1186/1471-2164-8-453 |
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