Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates
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* Corresponding authors: Susan M Kraemer sue.kraemer@sbri.org - Joseph D Smith joe.smith@sbri.org
BMC Genomics 2007, 8:45 doi:10.1186/1471-2164-8-45
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Research
Antoine Claessens, Ashfaq Ghumra, Archna P Gupta, Sachel Mok, Zbynek Bozdech, J Alexandra Rowe Malaria Journal 2011, 10:180 (30 June 2011) The authors have extended a MicroArray resource by adding members of different variant surface antigen (VSA) gene families and then using this new chip to identify the genes involved with a specific adherence phenotype (rosetting). This confirms that cytoadherence studies have been right to concentrate on PfEMP1.
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Research
Assessing the burden of pregnancy-associated malaria under changing transmission settings Mario Recker, Menno J Bouma, Paul Bamford, Sunetra Gupta, Andy P Dobson Malaria Journal 2009, 8:245 (28 October 2009) The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.
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Research
Kim JM Brolin, Ulf Ribacke, Sandra Nilsson, Johan Ankarklev, Kirsten Moll, Mats Wahlgren, Qijun Chen Genome Biology 2009, 10:R117 (22 October 2009) Duplicated var2csa genes in one strain of Plasmodium falciparum are simultaneously transcribed, challenging the dogma of mutual exclusive var gene transcription |
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Research article
Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes Nicolas Smargiasso, Valérie Gabelica, Christian Damblon, Frédéric Rosu, Edwin De Pauw, Marie-Paule Teulade-Fichou, J Rowe, Antoine Claessens BMC Genomics 2009, 10:362 (6 August 2009) |
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Research
Mario Recker, Nimalan Arinaminpathy, Caroline O Buckee Malaria Journal 2008, 7:18 (23 January 2008) |
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Methodology
Uta Gölnitz, Letusa Albrecht, Gerhard Wunderlich Malaria Journal 2008, 7:14 (14 January 2008) Enrichment of phenotypically homogenous parasites by panning on receptor expressing cells is fundamental for the identification of the corresponding var transcript. The paper shows that, at least for 3D7, transfected CHO cell lines are of limited use for the creation of monophenotypic cytoadherent parasite lines.
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