Table 5

Genes From 228 Cluster With Conserved Sp1 Sites

Gene Name; Aliases

Symbol

Evidence Related to Sp-Like Factors

Reference


5'-nucleotidase, cytosolic III

Nt5c3

Unknown

Activating transcription factor 3

Atf3

Induced by deferroxamine treatment; Sp1 reg. unknown

Oncogene 26(2):284-9, 2007.

Ankyrin repeat domain 37

Ankrd37

Unknown

Aquaporin 4

Aqp4

Promoter has consensus Sp1 sites

Genomics 50(3):373-7, 1998.

ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)

Atp7a

Unknown

ATP-binding cassette, sub-family G (WHITE), member 2

Abcg2

Several consensus Sp1 sites within minimal functional promoter

Biochim. Biophys. Acta. 1520(3):234-41, 2001.

Axin 2 (conductin, axil)

Axin2

Unknown

BCL2-like 11 (apoptosis facilitator)

Bcl2l11

Bcl2l11 inc. with apoptosis; enrichment for Sp1/Sp3 sites

Biochim. Biophys. Acta1693:167–176, 2004.

Tubulin polymerization-promoting protein; Brain-specific protein p25 alpha

Tppp

Unknown

Calponin 3, acidic

Cnn3

Unknown

Chemokine (C-C motif) ligand 20

Ccl20

Reg. by Sp1; MIP-3alpha

J. Biol. Chem. 278(2):875-84, 2003.

Cytochrome B Reductase 1

Cybrd1

Unknown

Cytochrome P450, family 51, subfamily A, polypeptide 1

Cyp51a1

Sp1 maximizes sterol regulation of promoter

Molecular Endocrinology 16 (8): 1853–1863, 2002.

DNA-damage-inducible transcript 4

Ddit4

Sp1 regulation; hypoxic induction

Pharm. Res. 21(5):736-41, 2004.

Early growth response 1

Egr1

Binds and inhibits Sp1

Am. J. Physiol. Renal Physiol. 284(6):F1216-25, 2003.

Egr1

Promoter has consensus Sp1 sites

Oncogene 6(5):867-71, 1991.

Egr1

Sp1 activates Egr1 gene expression

J. Biol. Chem. 268(23):16949-57, 1993.

Egr1

Sp1 and Egr1 bind similar GC rich

Biochem. Biophys. Res. Commun. 194(3):1475-82, 1993.

Ephrin A3

Efna3

Unknown

ERO1-like (S. cerevisiae); Endoplasmic oxidoreductin-1-like protein

Ero1l

Reg. by hypoxia and Df; Sp1 regulation unknown

Eur. J. Biochem. 270(10):2228-35, 2003.

Farnesyltransferase, CAAX box, beta

Fntb

Unknown

Gap junction protein, beta 2, 26 kDa; Connexin 26

Gjb2

Human gene reg. by Sp1/Sp3

Biochim. Biophys. Acta. 1443(1–2):169-81, 1998.

Glutathione peroxidase 2 (gastrointestinal)

Gpx2

Contains Sp1 elements

Gene 248(1–2):109-16, 2000.

Heme oxygenase 1

Hmox1

Functional Sp1-like site present in PI3 kinase responsive region

Free Radic. Biol. Med. 15;41(2):247-61, 2006.

Jumonji domain containing 1A

Jmjd1a

Unknown

Metallothionein 1A

Mt1a

Sp1 interacts with chicken Mt promoter

Comp. Biochem. Physiol. Biochem. Mol. Biol. 116(1):75–86, 1997.

Mt1a

Sp1 interacts with mouse Mt1 promoter

Biochem. J. 323 (Pt 1):79–85, 1997.

Mt1a

Sp1 interacts with metal response element in Mt promoter

FEBS Lett. 416(3):254-8, 1997.

Mt1a

Sp1 interacts with Mt1 promoter

J. Neurosci. 20(14):5200-7, 2000.

Mt1a

Sp1 interacts with Mt1 promoter

Nucleic Acids Res. 31(23):6710-21, 2003.

Peripheral myelin protein 22

Pmp22

Unknown

Phosphoglycerate kinase 1

Pgk1

Sp1 interacts with promoter; In vivo footprinting

Genes Dev. 4(8):1277-87, 1990.

Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

P4ha1

Unknown

Proliferating cell nuclear antigen

Pcna

3 conserved Sp1 sites present in murine promoter

DNA Seq. 2(3):181-91, 1991.

Ras homolog gene family, member B

RhoB

Contains Sp1 sites

J. Biol. Chem. 272(49):30637-44, 1997.

RhoB

Promoter contains consensus Sp1 sites

Biochem. Biophys. Res. Commun. 226(3):688-94, 1996.

Rictor; FYN binding protein (FYB-120/130)

Rictor

Unknown

Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

Spr

Promoter contains Sp1 sites

Biochem. Biophys. Res. Commun. 251(2):597–602, 1998.

Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Slc11a2

Promoter contains Sp1 sites

Blood Cells Mol. Dis. 24(2):199–215, 1998.

Solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Slc6a6

Promoter cloning paper

Adv. Exp. Med. Biol. 483:97–108, 2000.

Syndecan 1

Sdc1

Promoter reg. by Sp1 factor(s)

J. Biol. Chem. 271(21):12532-41, 1996.

TGFB-induced factor (TALE family homeobox)

Tgif

Unknown

TIMP metallopeptidase inhibitor 1

Timp1

Sp1 basal and hypoxic regulation

J. Cell. Biochem. 91(6):1260-8, 2004.

Timp1

Sp1 invovled in induction by TGF-beta

J. Cell. Physiol. 203(2):345-52, 2005.

Timp1

Sp1 invovled in induction by TGF-beta

Mol. Cancer Res. 4(3):209-20, 2006.

Timp1

Sp1 binding increased by leptin treatment

Mol. Endocrinol. 20(12):3376-88, 2006.

Transferrin receptor (p90, CD71)

Tfrc

Contains a GC rich region

Oncogene 21(52):7933-44, 2002.

Tripartitie motif protein 27

Trim27

Sp1 involved in promoter activity

Biochem. Biophys. Res. Commun. 261(2):381-4, 1999.

Tubulin-specific chaperone c

Tbcc

Unknown


Collins and Hu BMC Genomics 2007 8:420   doi:10.1186/1471-2164-8-420

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