Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions

doi:10.1186/1471-2164-8-407

BMC Genomics

Volume 8

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Venancio TM
DeMarco R
Almeida GT
Oliveira KC
Setubal JC
Verjovski-Almeida S

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DeMarco R
Almeida GT
Oliveira KC
Setubal JC
Verjovski-Almeida S
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Research article

Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions

Thiago M Venancio¹ , Ricardo DeMarco² , Giulliana T Almeida² , Katia C Oliveira² , João C Setubal³ and Sergio Verjovski-Almeida¹^,2

¹Laboratory of Bioinformatics; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

²Laboratory of Gene Expression in Eukaryotes; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

³Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

author email corresponding author email

BMC Genomics 2007, 8:407doi:10.1186/1471-2164-8-407


Published:	8 November 2007

Additional files

Additional file 1:

Schematic representation of the relationships between S. mansoni and three different clades and indication of the several groups that result from the presence or absence of S. mansoni genes among the organisms of each of the three clades.

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Additional file 2:

List of group 2 genes (conserved in schistosomes and deuterostomes, but lost in nematodes and arthropods). This table provides full statistics about query and hit coverage, identity and similarity percentages and annotations. Column "P" represents the presence (1) or absence (0) of a planarian homolog. The first four entries are for the three genes that were further characterized in this work.

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Additional file 3:

Conserved domains in SmIRF. A: BLAST analysis against the SWISSPROT database. A conserved N-terminal DNA-binding domain in SmIRF can be easily detected. B: In silico analysis of SmIRF using NetPhos revealed the presence of several Serine phosphorylation sites, important for IRF function and regulation.

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Additional file 4:

Primers used in the Real-time RT-PCR and RACE experiments.

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