Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets

doi:10.1186/1471-2164-8-404

BMC Genomics

Volume 8

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Grayson TH
Ohms SJ
Brackenbury TD
Meaney KR
Peng K
Pittelkow YE
Wilson SR
Sandow SL
Hill CE

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Grayson TH
Ohms SJ
Brackenbury TD
Meaney KR
Peng K
Pittelkow YE
Wilson SR
Sandow SL
Hill CE
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Research article

Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets

T Hilton Grayson¹ , Stephen J Ohms² , Therese D Brackenbury¹ , Kate R Meaney¹ , Kaiman Peng² , Yvonne E Pittelkow³ , Susan R Wilson³ , Shaun L Sandow⁴ and Caryl E Hill¹

¹Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia

²Australian Cancer Research Foundation Biomolecular Resource Facility, John Curtin School of Medical Research, Australian National University, Canberra, Australia

³Centre for Bioinformation Science, Mathematical Sciences Institute, Australian National University, Canberra, Australia

⁴School of Medical Sciences, University of New South Wales, Sydney, Australia

author email corresponding author email

BMC Genomics 2007, 8:404doi:10.1186/1471-2164-8-404


Published:	7 November 2007

Additional files

Additional file 1:

Genes with increased expression in ACTH vs WKY and unchanged in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 49KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

Genes with decreased expression in ACTH vs WKY and unchanged in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 67KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 3:

Genes with increased expression in SHR vs WKY and unchanged in ACTH vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 77KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 4:

Genes with decreased expression in SHR vs WKY and unchanged in ACTH vs WKY. Description of dataset: Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 73KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 5:

Genes with increased expression in ACTH and SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 41KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 6:

Genes with decreased expression in ACTH and SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 49KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 7:

Genes with increased expression in ACTH vs WKY and decreased expression in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 24KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 8:

Genes with decreased expression in ACTH vs WKY and increased expression in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 25KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 9:

Genes with increased expression in ACTH vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 83KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 10:

Genes with decreased expression in ACTH vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 108KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 11:

Genes with increased expression in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 110KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 12:

Genes with decreased expression in SHR vs WKY. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 114KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 13:

Genes with increased expression in SHR vs ACTH. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 138KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 14:

Genes with decreased expression in SHR vs ACTH. Gene lists of statistical analysis of microarray data including gene names, gene descriptions, biological function, Affymetrix IDs, accession numbers, expression levels and p-values.

Format: XLS Size: 115KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 15:

Density plots and boxplots of log₂CEL file intensities. A. The density plots showed the expected right-skewed distribution. There was no evidence of scanner saturation. B. Boxplots showed a consistent shape and size which indicated consistency between samples.

Format: PDF Size: 85KB Download file

This file can be viewed with: Adobe Acrobat Reader