|
Homology relationships between the kinomes of S. cerevisiae, S. pombe and E. cuniculi |
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| AGC family |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| AKT |
YPK1, YPK2 |
SPCC24B10.07 (gad8) |
Viable (Sc, Sp) |
|
| AKT |
SCH9 |
SPAC1B9.02c (sck1), SPAC22E12.14c (sck2) |
Viable (Sc, Sp) |
|
| AUR |
IPL1 |
SPCC320.13c (ark1) |
CAD25568.1 |
Lethal (Sc, Sp) |
| BUB |
BUB1 |
SPCC1322.12c (bub1) |
Viable (Sc, Sp) |
|
| NDR |
RIM15 |
SPAPB18E9.02c (ppk18), SPCC1450.11c (cek1) |
Viable (Sc, Sp) |
|
| NDR |
CBK1 |
SPAC821.12 (orb6) |
CAD25005.1 |
Lethal (Sc, Sp) |
| NDR |
DBF2, DBF20 |
SPCC417.06c (ppk35), SPAC24B11.11c (sid2) |
Lethal (sid2) |
|
| PDK1 |
PKH1, PKH2 |
SPCC576.15c (ksg1) |
Lethal (ksg1) |
|
| PDK1 |
YDR466W (PKH3) |
SPBC1778.10c (ppk21) |
Viable (Sc, Sp) |
|
| PKA |
TPK1, TPK2, TPK3 |
SPBC106.10 (pka1) |
CAD25584.1 |
Viable (Sc, Sp) |
| PKC |
PKC1 |
SPAC17G8.14c (pck1), SPBC12D12.04c (pck2) |
Lethal (PKC1) |
|
| RSK |
KIN82 |
SPBC1861.09 (ppk22) |
Viable (Sc, Sp) |
|
| RSK |
YNR047W |
SPAC4G8.05 (ppk14) |
Viable (Sc, Sp) |
|
| RSK |
YBR028C |
SPCC4G3.08 (psk1) |
Viable (Sc, Sp) |
|
| AGC unpaired |
AGC unpaired |
AGC unpaired |
||
| YKL171W |
SPBC725.06c (ppk31) |
CAD25776.1 |
||
| SPCC162.10 (cmk2) |
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|
|
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| CAMK family |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| CAMK1 |
CMK1, CMK2 |
SPACUNK12.02c (cmk1) |
Viable (Sc, Sp) |
|
| CAMK1 |
RCK1, RCK2 |
SPAC23A1.06c (cmk2), SPCC1322.08 (srk1) |
Viable (Sc, Sp) |
|
| CAMKK |
TOS3, PAK1 |
SPCC297.03 (ssp1), SPCC1919.01 (ppk34) |
Viable (Sc, Sp) |
|
| CAMKL |
CHK1 |
SPCC1259.13 (chk1) |
CAD26208.1 |
Viable (Sc, Sp) |
| CAMKL |
KIN1, KIN2 |
SPBC4F6.06 (kin1), SPBC32C12.03c (ppk25) |
CAD26242.1, CAD26452.1 |
Viable (Sc, Sp) |
| CAMKL |
KIN4, YPL141C |
SPAC110.01 (ppk1) |
Viable (Sc, Sp) |
|
| CAMKL |
YPL150W |
SPAC890.03 (ppk16) |
Viable (Sc, Sp) |
|
| CAMKL |
FUN31, YOL045W |
SPAC1805.01c (ppk6) |
Viable (Sc, Sp) |
|
| CAMKL |
SNF1 |
SPCC74.03c (ssp2), SPAC23H4.02 (ppk9) |
Viable (Sc, Sp) |
|
| CAMKL |
KCC4, GIN4, HSL1 |
SPAC644.06c (cdr1), SPAC57A10.02 (cdr2) |
Viable (Sc, Sp) |
|
| CAMK-Unique |
MEK1 |
SPAC14C4.03 (mek1) |
Viable (Sc, Sp) |
|
| CAMK-Unique |
PRR1 |
SPBC337.04 (ppk27) |
Viable (Sc, Sp) |
|
| HAL |
SAT4 |
SPAC29A4.16 (ppk10) |
Viable (Sc, Sp) |
|
| HAL |
YOR267C, YDL025C |
SPCC1020.10 (oca2) |
Viable (Sc, Sp) |
|
| RAD53 |
RAD53 |
SPCC18B5.11c (cds1) |
Lethal (RAD53) |
|
| RAN |
KSP1 |
SPBC16E9.13 (ppk20) |
Viable (Sc, Sp) |
|
| ULK |
APG1 |
SPCC63.08c (ppk36) |
Viable (Sc, Sp) |
|
| CAMK unpaired |
CAMK unpaired |
CAMK unpaired |
||
| (PTK1, PTK2) |
SPAC22G7.08 (ppk8) |
CAD26060.1 |
||
| (HAL5, KKQ8) |
(SPCC70.05c (ppk37, Lethal), SPBC21.07c (ppk24)) |
CAD25086.1 |
||
| DUN1 |
SPBC19C2.05 |
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| YMR291W |
SPAC15A10.13 |
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| (NPR1, PRR2) |
SPBP23A10.10 |
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| IKS1 |
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| YGR052W |
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| ISR1 |
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|
|
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| CK1 family |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| CK1 |
YCK1 |
SPAC1805.05 (cki3) |
||
| CK1 |
YCK2 |
SPBC1347.06c (cki1) |
||
| CK1 |
YCK3 |
SPBP35G2.05c (cki2) |
||
| CK1 |
HRR25 |
SPBC3H7.15 (hhp1) |
CAD26235.1 |
Lethal (HRR25) |
| SPAC23C4.12 (hhp2) |
CAD26108.1 |
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|
|
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| CMGC family |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| CDC7 |
CDC7 |
SPBC776.12c (hsk1), SPBC21C3.18 (spo4) |
CAD26498.1, CAD25731.1 |
Lethal (CDC7, hsk1) |
| CDK |
KIN28 |
SPBC19F8.07 (crk1) |
CAD25174.1 |
Lethal (KIN28, crk1) |
| CDK |
CDC28 |
SPBC11B10.09 (cdc2) |
CAD26495.1 |
Lethal (CDC28, cdc2) |
| CDK |
CTK1 |
SPAC2F3.15 (lsk1) |
CAD26006.1 |
Viable (Sc, Sp) |
| CDK |
CAK1 |
SPAC1D4.06c (csk1) |
Lethal (CAK1) |
|
| CDK |
SGV1 |
SPBC32H8.10 (cdk9) |
Lethal (SGV1, cdk9) |
|
| CDK |
PHO85 |
SPCC16C4.11 (pef1) |
Viable (Sc, Sp) |
|
| CDK |
SSN3 |
SPAC23H4.17c (srb10) |
Viable (Sc, Sp) |
|
| CK2 |
CKA1, CKA2 |
SPAC23C11.11 (cka1) |
CAD26671.1 |
Lethal (cka1) |
| CLK |
KNS1 |
SPAC1D4.11c (lkh1) |
Viable (Sc, Sp) |
|
| DYRK |
YAK1 |
SPAC823.03 (ppk15) |
CAD25928.1 |
Viable (Sc, Sp) |
| GSK |
RIM11, MRK1 |
SPBC8D2.01 (gsk31), SPAC1687.15 (gsk3) |
Viable (Sc, Sp) |
|
| MAPK |
FUS3, KSS1 |
SPAC31G5.09c (spk1) |
Viable (Sc, Sp) |
|
| MAPK |
HOG1 |
SPAC24B11.06c (sty1) |
Viable (Sc, Sp) |
|
| MAPK |
SLT2, YKL161C |
SPBC119.08 (pmk1) |
Viable (Sc, Sp) |
|
| RCK |
IME2 |
SPAC3C7.06c (pit1), SPBC8D2.19 (mde3) |
Viable (Sc, Sp) |
|
| SRPK |
SKY1 |
SPBC530.14c (dsk1) |
Viable (Sc, Sp) |
|
| TTK |
MPS1 |
SPBC106.01 (mph1) |
CAD25082.1 |
Lethal (MPS1) |
| CMGC unpaired |
CMGC unpaired |
CMGC unpaired |
||
| SMK1 |
SPAC16C9.07 (ppk5), SPAC2F7.03c (pom1) |
CAD25660.1 |
||
| (MCK1, YOL128C) |
SPCC777.14 (prp4, Lethal) |
(CAD26039.1, CAD26483.1) |
||
| SPBC336.14C |
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| SPBC18H10.15 (ppk23) |
CAD26328.1 |
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|
|
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| STE family |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| STE7 |
PBS2 |
SPBC409.07c (wis1) |
(none) |
Viable (Sc, Sp) |
| STE7 |
MKK1, MKK2 |
SPBC543.07 (pek1) |
Viable (Sc, Sp) |
|
| STE7 |
STE7 |
SPAC1D4.13 (byr1) |
Viable (Sc, Sp) |
|
| STE20 |
STE20 |
SPBC1604.14c (shk1) |
Lethal (shk1) |
|
| STE20 |
CLA4, SKM1 |
SPAC1F5.09c (shk2) |
Viable (Sc, Sp) |
|
| STE20 |
SPS1 |
SPAC2C4.14c (ppk11), SPAC9G1.09 (sid1) |
Lethal (sid1) |
|
| STE20 |
CDC15 |
SPBC21.06c (cdc7) |
Lethal (CDC15, cdc7) |
|
| STE20 |
KIC1 |
SPBC17F3.02 (nak1) |
Lethal (KIC1, nak1) |
|
| STE11 |
SSK2, SSK22 |
SPAC1006.09 (win1), SPAC9G1.02 (wis4) |
Viable (Sc, Sp) |
|
| STE11 |
STE11 |
SPBC1D7.05 (byr2) |
Viable (Sc, Sp) |
|
| STE11 |
BCK1 |
SPAC1F3.02c (mkh1) |
Viable (Sc, Sp) |
|
|
|
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| Other group |
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|
|
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| Sub-family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| Bud32 |
BUD32 |
SPAP27G11.07c$$ |
CAD25400.1 |
Viable (BUD32) |
| GCN2 |
GCN2 |
SPAC20G4.03c (hri1) |
Viable (Sc, Sp) |
|
| IRE |
IRE1 |
SPAC167.01 (ppk4) |
Viable (Sc, Sp) |
|
| NAK |
YPL236C |
SPAC3H1.13 (ppk13) |
Viable (Sc, Sp) |
|
| NAK |
AKL1, PRK1, ARK1 |
SPCP1E11.02 (ppk38), SPBC6B1.02 (ppk30), SPBC557.04 (ppk29) |
Viable (Sc, Sp) |
|
| NEK |
KIN3 |
SPAC19E9.02 (fin1) |
Viable (Sc, Sp) |
|
| PLK |
CDC5 |
SPAC23C11.16 (plo1) |
CAD24933.1 |
Lethal (CDC5, plo1) |
| VPS15 |
VPS15 |
SPBC119.07 (ppk19) |
Viable (Sc, Sp) |
|
| WEE |
SWE1 |
SPCC18B5.03 (wee1), SPBC660.14 (mik1) |
CAD26466.1 |
Viable (Sc, Sp) |
| Other unpaired |
Other unpaired |
Other unpaired |
||
| SCY1 |
SPBC15C4.02$$ |
CAD26209.1 |
||
| ELM1 |
SPAC12B10.14c (ppk2) |
CAD26233.1 |
||
| SPAC23C4.03$$ |
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| SPAC222.07c (hri2) |
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| SPBC36B7.09 (ppk28) |
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|
|
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| TKL family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| (none) |
(none) |
CAD26582.1 |
Unknown |
|
|
|
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| PIKK family |
S. cerevisiae |
S. pombe |
E. cuniculi |
Deletion mutant |
|
|
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| MEC1 |
SPBC216.05 |
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| TEL1 |
SPCC23B6.03c * |
CAD25142.1, CAD25955.1 |
||
| TOR1 |
SPBC216.07c |
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| TOR2 |
SPBC30D10.10c |
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| TRA1 |
SPAC1F5.11c |
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|
|
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| RIO family |
S. cerevisiae |
S. pombe |
E. cuniculi |
|
|
|
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| RIO1 |
SPAC10F6.10 |
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| RIO2 |
SPBC1703.05 |
CAD26627.1 |
||
|
|
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| PDHK family |
S. cerevisiae |
S. pombe |
E. cuniculi |
|
|
|
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| YGL059W |
(none) |
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| YIL042C |
SPAC644.11c |
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|
$$novel; no information on these S pombe kinases * SPAC22E12.16c, SPBC577.06c, and SPAC458.05 are TEL1-related | ||||
Miranda-Saavedra et al. BMC Genomics 2007 8:309 doi:10.1186/1471-2164-8-309 |
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