Table 2

Reversible gene expression upon smoking cessation related to xenobiotic metabolism and DNA adduct formation (genes in bold have not been previously associated with smoking)
Tag
 Gene Symbol
 Gene Name
 CS Mean*
 FS Mean*
 NS Mean*
 P-Value (CVsF)
GGCCCAGGCC
 ALDH3A1
 Aldehyde dehydrogenase 3 family, memberA1
 4355
 313
 261
 0.00002
TTAAAAATTC
 ADH7
 Alcohol dehydrogenase 7 (class IV)
 899
 145
 130
 0.00002
AGGTCTGCCA***
 AKR1C2
 Aldo-keto reductase family 1, member C2
 547
 116
 74
 0.00002
AATGCTTTTA
 CYP1B1
 Cytochrome P450, family 1, subfamily B, polypeptide 1
 204
 13
 0
 0.00002
TTGGAATCCA
 STAU2
 Staufen, RNA binding protein, homolog 2 (Drosophila)
 67
 17
 23
 0.00002
TTATCAAATC
 NQO1
 NAD(P)H dehydrogenase, quinone 1
 809
 202
 149
 0.00003
CAAATAAACC
 PIR
 Pirin (iron-binding nuclear protein)
 260
 47
 43
 0.00003
GGCCCCATTT
 CBR1
 Carbonyl reductase 1
 144
 31
 24
 0.00003
TATTTTTGTT
 TXNRD1
 Thioredoxin reductase 1
 250
 88
 78
 0.00006
GGTGGTGTCT
 GPX2
 Glutathione peroxidase 2 (gastrointestinal)
 384
 40
 46
 0.00011
TATTTTTGAA
 DRB1
 Developmentally regulated RNA-binding protein 1
 204
 32
 22
 0.00011
TGGGAGTGGG**
 NMNAT2
 Nicotinamide nucleotide adenylyltransferase 2
 175
 17
 9
 0.00011
CAAGACCAGT
 GSTA2
 Glutathione S-transferase A2
 1436
 485
 528
 0.00019
GCTTGAATAA
 AKR1B10
 Aldo-keto reductase family 1, member B10 (aldose reductase)
 332
 10
 15
 0.0003
GTGCAGGGAG
 SPDEF
 SAM pointed domain containing ets transcription factor
 239
 64
 50
 0.0003
GGAGGCTTCC
 MECR
 Mitochondrial trans-2-enoyl-CoA reductase
 85
 26
 22
 0.0003
GTGATGTAAG
 SRXN1
 Sulfiredoxin 1 homolog (S. cerevisiae)
 63
 14
 11
 0.0003
TATGCTTTAA
 NT5DC1
 5'-nucleotidase domain containing 1
 59
 23
 24
 0.0003
GAACGCCTAA
 DPYSL2
 Dihydropyrimidinase-like 2
 1
 21
 23
 0.0004
TTTTCTGAAA
 TXN
 Thioredoxin
 698
 326
 212
 0.00048
CTTGCATAAG
 CYP1A1
 Cytochrome P450, family 1, subfamily A, polypeptide 1
 89
 2
 0
 0.00048
GCAAGAAGAG
 ALDH3A1
 Aldehyde dehydrogenase 3 family, memberA1
 77
 10
 2
 0.00048
AGAACAAAAC
 PRDX1
 Peroxiredoxin 1
 1043
 418
 510
 0.00071
AAATATTTAA
 SLC35A3
 Solute carrier family 35, member A3
 47
 14
 19
 0.00071
CGGCTGAATT
 PGD
 Phosphogluconate dehydrogenase
 252
 104
 80
 0.00106
CTTATCAGTA
 BTBD7
 BTB (POZ) domain containing 7
 94
 22
 2
 0.00106
AAGAGTTTTG
 AKR1B1
 Aldo-keto reductase family 1, member B1 (aldose reductase)
 25
 5
 6
 0.00141
GCTGAGATGA**
 CYP4F11
 Cytochrome P450, family 4, subfamily F, polypeptide 11
 22
 6
 2
 0.00141
GGCGCCTCCT
 TALDO1
 Transaldolase 1
 232
 76
 94
 0.00152
GACACAGCAA
 ENTPD8
 Ectonucleoside triphosphate diphosphohydrolase 8
 24
 3
 2
 0.00159
CAGTCTAAAA
 UCHL1
 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
 92
 4
 0
 0.00197
ACATCCTAGG
 ALDH1A1
 Aldehyde dehydrogenase 1 family, member A1
 60
 28
 30
 0.00216
TTAGAAGGAA
 NQO1
 NAD(P)H dehydrogenase, quinone 1
 41
 14
 9
 0.00216
AGGTCTACCA
 AKR1C2
 Aldo-keto reductase family 1, member C2
 270
 32
 8
 0.00292
ATTAGGCCTG
 TXNRD1
 Thioredoxin reductase 1
 51
 19
 17
 0.00297
GAGAGCTTTG
 AKR1C3
 Aldo-keto reductase family 1, member C3
 149
 21
 22
 0.00298
TACGCTTGGT
 CYB5R1
 Cytochrome b5 reductase 1
 68
 32
 30
 0.00298
CACTGCCTTG
 FTH1
 Ferritin, heavy polypeptide 1
 59
 23
 17
 0.00298
CTGCTGCACT
 GSR
 Glutathione reductase
 126
 54
 50
 0.0041
GGCAAAATTA
 SLC35A3
 Solute carrier family 35, member A3
 73
 32
 35
 0.0041
ACCTTGGGGT
 NQO1
 NAD(P)H dehydrogenase, quinone 1
 73
 19
 6
 0.0041
AATGTTCAGG
 COQ6
 Coenzyme Q6 homolog, monooxygenase (yeast)
 29
 12
 4
 0.00708
CACTGACCAG
 NOD27
 Nucleotide-binding oligomerization domains 27
 31
 10
 0
 0.00927
CTCGGAGGCC
 SEPX1
 Selenoprotein X, 1
 71
 32
 28
 0.00956
CTCCAAAAAA
 CPSF2
 Cleavage and polyadenylation specific factor 2, 100 kDa
 118
 44
 14
 0.02013
AATGGAAACT
 GCLM
 Glutamate-cysteine ligase, modifier subunit
 34
 16
 9
 0.03186

*Mean in tags per million (TPM)

** Changed mapping with TAGMapper [56]

***Tag maps with equal reliability to AKR1C1

Chari et al. BMC Genomics 2007 8:297   doi:10.1186/1471-2164-8-297