Table 2

Reversible gene expression upon smoking cessation related to xenobiotic metabolism and DNA adduct formation (genes in bold have not been previously associated with smoking)

Tag

Gene Symbol

Gene Name

CS Mean*

FS Mean*

NS Mean*

P-Value (CVsF)


GGCCCAGGCC

ALDH3A1

Aldehyde dehydrogenase 3 family, memberA1

4355

313

261

0.00002

TTAAAAATTC

ADH7

Alcohol dehydrogenase 7 (class IV)

899

145

130

0.00002

AGGTCTGCCA***

AKR1C2

Aldo-keto reductase family 1, member C2

547

116

74

0.00002

AATGCTTTTA

CYP1B1

Cytochrome P450, family 1, subfamily B, polypeptide 1

204

13

0

0.00002

TTGGAATCCA

STAU2

Staufen, RNA binding protein, homolog 2 (Drosophila)

67

17

23

0.00002

TTATCAAATC

NQO1

NAD(P)H dehydrogenase, quinone 1

809

202

149

0.00003

CAAATAAACC

PIR

Pirin (iron-binding nuclear protein)

260

47

43

0.00003

GGCCCCATTT

CBR1

Carbonyl reductase 1

144

31

24

0.00003

TATTTTTGTT

TXNRD1

Thioredoxin reductase 1

250

88

78

0.00006

GGTGGTGTCT

GPX2

Glutathione peroxidase 2 (gastrointestinal)

384

40

46

0.00011

TATTTTTGAA

DRB1

Developmentally regulated RNA-binding protein 1

204

32

22

0.00011

TGGGAGTGGG**

NMNAT2

Nicotinamide nucleotide adenylyltransferase 2

175

17

9

0.00011

CAAGACCAGT

GSTA2

Glutathione S-transferase A2

1436

485

528

0.00019

GCTTGAATAA

AKR1B10

Aldo-keto reductase family 1, member B10 (aldose reductase)

332

10

15

0.0003

GTGCAGGGAG

SPDEF

SAM pointed domain containing ets transcription factor

239

64

50

0.0003

GGAGGCTTCC

MECR

Mitochondrial trans-2-enoyl-CoA reductase

85

26

22

0.0003

GTGATGTAAG

SRXN1

Sulfiredoxin 1 homolog (S. cerevisiae)

63

14

11

0.0003

TATGCTTTAA

NT5DC1

5'-nucleotidase domain containing 1

59

23

24

0.0003

GAACGCCTAA

DPYSL2

Dihydropyrimidinase-like 2

1

21

23

0.0004

TTTTCTGAAA

TXN

Thioredoxin

698

326

212

0.00048

CTTGCATAAG

CYP1A1

Cytochrome P450, family 1, subfamily A, polypeptide 1

89

2

0

0.00048

GCAAGAAGAG

ALDH3A1

Aldehyde dehydrogenase 3 family, memberA1

77

10

2

0.00048

AGAACAAAAC

PRDX1

Peroxiredoxin 1

1043

418

510

0.00071

AAATATTTAA

SLC35A3

Solute carrier family 35, member A3

47

14

19

0.00071

CGGCTGAATT

PGD

Phosphogluconate dehydrogenase

252

104

80

0.00106

CTTATCAGTA

BTBD7

BTB (POZ) domain containing 7

94

22

2

0.00106

AAGAGTTTTG

AKR1B1

Aldo-keto reductase family 1, member B1 (aldose reductase)

25

5

6

0.00141

GCTGAGATGA**

CYP4F11

Cytochrome P450, family 4, subfamily F, polypeptide 11

22

6

2

0.00141

GGCGCCTCCT

TALDO1

Transaldolase 1

232

76

94

0.00152

GACACAGCAA

ENTPD8

Ectonucleoside triphosphate diphosphohydrolase 8

24

3

2

0.00159

CAGTCTAAAA

UCHL1

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

92

4

0

0.00197

ACATCCTAGG

ALDH1A1

Aldehyde dehydrogenase 1 family, member A1

60

28

30

0.00216

TTAGAAGGAA

NQO1

NAD(P)H dehydrogenase, quinone 1

41

14

9

0.00216

AGGTCTACCA

AKR1C2

Aldo-keto reductase family 1, member C2

270

32

8

0.00292

ATTAGGCCTG

TXNRD1

Thioredoxin reductase 1

51

19

17

0.00297

GAGAGCTTTG

AKR1C3

Aldo-keto reductase family 1, member C3

149

21

22

0.00298

TACGCTTGGT

CYB5R1

Cytochrome b5 reductase 1

68

32

30

0.00298

CACTGCCTTG

FTH1

Ferritin, heavy polypeptide 1

59

23

17

0.00298

CTGCTGCACT

GSR

Glutathione reductase

126

54

50

0.0041

GGCAAAATTA

SLC35A3

Solute carrier family 35, member A3

73

32

35

0.0041

ACCTTGGGGT

NQO1

NAD(P)H dehydrogenase, quinone 1

73

19

6

0.0041

AATGTTCAGG

COQ6

Coenzyme Q6 homolog, monooxygenase (yeast)

29

12

4

0.00708

CACTGACCAG

NOD27

Nucleotide-binding oligomerization domains 27

31

10

0

0.00927

CTCGGAGGCC

SEPX1

Selenoprotein X, 1

71

32

28

0.00956

CTCCAAAAAA

CPSF2

Cleavage and polyadenylation specific factor 2, 100 kDa

118

44

14

0.02013

AATGGAAACT

GCLM

Glutamate-cysteine ligase, modifier subunit

34

16

9

0.03186


*Mean in tags per million (TPM)

** Changed mapping with TAGMapper [56]

***Tag maps with equal reliability to AKR1C1

Chari et al. BMC Genomics 2007 8:297   doi:10.1186/1471-2164-8-297

Open Data