Mutation in bldA has wide-ranging effects on secondary metabolism. The figure presents a stylised illustration of the 8.7 Mbp S. coelicolor linear chromosome, with the 21 genes or gene clusters that determine secondary metabolite production marked with arrows, and those that are altered in expression in M600 ΔbldA asterisked. The thick orange line represents the central core of the chromosome rich in essential functions and containing the origin of replication (ori).
Hesketh et al. BMC Genomics 2007 8:261 doi:10.1186/1471-2164-8-261