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Open Access Research article

V1R promoters are well conserved and exhibit common putative regulatory motifs

Robert Stewart and Robert P Lane*

Author Affiliations

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, 06459 USA

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BMC Genomics 2007, 8:253  doi:10.1186/1471-2164-8-253

Published: 25 July 2007

Additional files

Additional file 1:

Table of V1R gene names, locations, and subfamily designations. Excel spreadsheet itemizing all V1Rs used in this study.

Format: XLS Size: 146KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Conservation scores, peak definitions, putative transcription start site locations, and motif occurrences for the complete set of V1R gene blocks. Gene block conservation scores and sequence walks for 124 intact V1R genes are found at http://igs.wesleyan.edu/stewart_etal2006/SupplementaryA-SequenceWalks/ webcite. To view a gene block, first select a motif directory, then click on a V1R gene name (e.g., "V1ra1"). Coding regions (red), conservation peaks (green), and other regions of the block (blue) are shaded. Gray stripes denote RepeatMasked portions of the gene block. Empirical TSS's determined by 5' RACE are shaded light blue; homology to transcription start sites determined for another subfamily member are highlighted pink. Each horizontal tick mark represents 500 bp. Sequence walker motif occurrences are indicated by vertical lines with the height of the lines indicating individual information of each motif occurrence.

Format: PDF Size: 91KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

V1R peak sequences. Text file in fasta format of all putative promoter regions ("peaks") for all V1R sequences used in this study.

Format: DOC Size: 237KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data