Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific

doi:10.1186/1471-2164-8-234

BMC Genomics

Volume 8

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Hutchinson OC
Picozzi K
Jones NG
Mott H
Sharma R
Welburn SC
Carrington M

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Picozzi K
Jones NG
Mott H
Sharma R
Welburn SC
Carrington M
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Research article

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific

O Clyde Hutchinson¹^,3 , Kim Picozzi² , Nicola G Jones¹ , Helen Mott¹ , Reuben Sharma¹^,4 , Susan C Welburn² and Mark Carrington¹

¹Department of Biochemistry, 80 Tennis Court Road, Cambridge, CB2 1GA, UK

²Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, UK

³Institute of Zoology, Zoological Society of London, Regents Park, London, NW1 4RY, UK

⁴Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia

author email corresponding author email

BMC Genomics 2007, 8:234doi:10.1186/1471-2164-8-234


Published:	13 July 2007

Additional files

Additional file 1:

1. Map showing location where isolates were collected. 2. A comparison of VSGs AnTat1.1b and AnTat 1.10. 3. The following data are presented for each VSG : a) Amino acid sequence with cysteine residues in red. b) Domain combination. c) N-terminal domain sequences of homologues identified using the whole VSG sequence to screen the T. b. brucei TREU927 and T. b. gambiense Daloa genomic sequences. The N-terminal domain was standardised by ending 5 residues before first cysteine in the C-terminal domain. d) Percentage identities measured using NCBI blast 2 sequences. e) Three way alignment for the six VSGs used to determine the location of sequence divergence.

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