Table 4

Opisthorchis viverrini ESTs with sequence identity to mRNAs encoding proteins efficacious as vaccines against other flatworm and nematode parasites.

Predicted protein family

Vaccine antigen and helminth targeted

References

Aspartic protease

APR-1 for hookworm; cathepsin D for Schistosoma japonicum

[59, 60]

Glutathione-S-transferase

Ac-GST-1 for hookworm; bilvax for schistosomes

[79, 80]

Cysteine protease

TSBP for Haemonchus contortus; AcCP1 for hookworm; Cathepsins L1 and L2 for Fasciola hepatica

[61–63]

Tetraspanin

TSP-1, TSP-2 and Sm23 for Schistosoma mansoni

[33, 81]

Pathogenesis related protein

ASP-2 for hookworm; ASP-1 for Onchocerca volvulus

[82, 83]

calpain

Smp80 for schistosomes

[64]

Fatty acid binding protein

Sm14 for S. mansoni and F. hepatica

[66, 67]

Saposin-like protein

FhSAP-2 for F. hepatica

[65]

14-3-3

Sm14-3-3 for schistosomes

[84]

22.6 (unknown function)

Sm22.6 for S. mansoni

[58]

Laha et al. BMC Genomics 2007 8:189   doi:10.1186/1471-2164-8-189