The molecular portraits of breast tumors are conserved across microarray platforms
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* Corresponding author: Charles M Perou cperou@med.unc.edu
BMC Genomics 2006, 7:96 doi:10.1186/1471-2164-7-96
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The CD44+/CD24- phenotype is enriched in basal-like breast tumors Gabriella Honeth, Pär-Ola Bendahl, Markus Ringnér, Lao H Saal, Sofia K Gruvberger-Saal, Kristina Lövgren, Dorthe Grabau, Mårten Fernö, Åke Borg, Cecilia Hegardt Breast Cancer Research 2008, 10:R53 (17 June 2008) Basal-like and particularly BRCA1 hereditary breast cancer are associated with CD44+/CD24- cells, however tumorigenicity may not be confined to cells of this phenotype as they are found in very few HER2+ tumours.
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Cell cycle correlated genes dictate the prognostic power of breast cancer gene lists Jonathan D Mosley, Ruth A Keri BMC Medical Genomics 2008, 1:11 (25 April 2008) |
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MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype Cherie Blenkiron, Leonard D Goldstein, Natalie P Thorne, Inmaculada Spiteri, Suet-Feung Chin, Mark J Dunning, Nuno L Barbosa-Morais, Andrew E Teschendorff, Andrew R Green, Ian O Ellis, Simon Tavaré, Carlos Caldas, Eric A Miska Genome Biology 2007, 8:R214 (8 October 2007) Integrated analysis of miRNA expression and genomic changes in human breast tumors allows the classification of tumor subtypes. |
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Suet F Chin, Andrew E Teschendorff, John C Marioni, Yanzhong Wang, Nuno L Barbosa-Morais, Natalie P Thorne, Jose L Costa, Sarah E Pinder, Mark A van de Wiel, Andrew R Green, Ian O Ellis, Peggy L Porter, Simon Tavaré, James D Brenton, Bauke Ylstra, Carlos Caldas Genome Biology 2007, 8:R215 (7 October 2007) High resolution array-CGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer, and provides a genome-wide list of common copy number alterations associated with aberrant expression and poor prognosis. |
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Bas Kreike, Marieke van Kouwenhove, Hugo Horlings, Britta Weigelt, Hans Peterse, Harry Bartelink, Marc J van de Vijver Breast Cancer Research 2007, 9:R65 (2 October 2007) |
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Martin Buess, Dimitry SA Nuyten, Trevor Hastie, Torsten Nielsen, Robert Pesich, Patrick O Brown Genome Biology 2007, 8:R191 (14 September 2007) In an effort to deconvolute global gene-expression profiles, an interaction between some breast cancer cells and stromal fibroblasts was found to induce an interferon response, which may be associated with a greater propensity for tumor progression. |
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Andrew E Teschendorff, Ahmad Miremadi, Sarah E Pinder, Ian O Ellis, Carlos Caldas Genome Biology 2007, 8:R157 (2 August 2007) A feature selection method was used in an analysis of three major microarray expression datasets to identify molecular subclasses and prognostic markers in estrogen receptor-negative breast cancer, showing that it is a heterogeneous disease with at least four main subtypes. |
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EGFR associated expression profiles vary with breast tumor subtype Katherine A Hoadley, Victor J Weigman, Cheng Fan, Lynda R Sawyer, Xiaping He, Melissa A Troester, Carolyn I Sartor, Thais Rieger-House, Philip S Bernard, Lisa A Carey, Charles M Perou BMC Genomics 2007, 8:258 (31 July 2007) |
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Jason I Herschkowitz, Karl Simin, Victor J Weigman, Igor Mikaelian, Jerry Usary, Zhiyuan Hu, Karen E Rasmussen, Laundette P Jones, Shahin Assefnia, Subhashini Chandrasekharan, Michael G Backlund, Yuzhi Yin, Andrey I Khramtsov, Roy Bastein, John Quackenbush, Robert I Glazer, Powel H Brown, Jeffrey E Green, Levy Kopelovich, Priscilla A Furth, Juan P Palazzo, Olufunmilayo I Olopade, Philip S Bernard, Gary A Churchill, Terry Van Dyke, Charles M Perou Genome Biology 2007, 8:R76 (10 May 2007) Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human subtypes were conserved among mouse models. |
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Integrative analysis of a cancer somatic mutome Pilar Hernández, Xavier Solé, Joan Valls, Víctor Moreno, Gabriel Capellá, Ander Urruticoechea, Miguel Pujana Molecular Cancer 2007, 6:13 (5 February 2007) |
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A consensus prognostic gene expression classifier for ER positive breast cancer Andrew E Teschendorff, Ali Naderi, Nuno L Barbosa-Morais, Sarah E Pinder, Ian O Ellis, Sam Aparicio, James D Brenton, Carlos Caldas Genome Biology 2006, 7:R101 (31 October 2006) A consensus prognostic classifier for estrogen receptor positive breast tumors has been developed and shown to be valid in nearly 900 samples across different microarray platforms. |
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Andrew H Sims, Kai Ong, Robert B Clarke, Anthony Howell Breast Cancer Research 2006, 8:214 (11 October 2006) This article is part of a collection on High-throughput genomic... |