Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication

doi:10.1186/1471-2164-7-74

BMC Genomics
Volume 7

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Research article

Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication

Ziliang Qian³^,4 , Yanbin Yin² , Yong Zhang² , Lingyi Lu³^,4 , Yixue Li³ and Ying Jiang¹

¹Molecular and Investigative Toxicology, Merck Research Laboratories, WP45-330, West Point, PA 19486, USA

²College of Life Sciences, National Laboratory of Genetic Engineering and Protein Engineering, Center of Bioinformatics, Peking University, Beijing 100871, China

³Bioinformatics Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China

⁴Graduate School of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100039, China

author email corresponding author email

BMC Genomics 2006, 7:74doi:10.1186/1471-2164-7-74


Published:	5 April 2006

Additional files

Additional File 1:

new TarB sequences.fasta. New TarB sequences identified by NCBI ORFinder

Format: FAST Size: 1KB Download file

Additional File 2:

The tar and tag orthologs in S. aureus. Identity and E-value are shown here. Newly identified TarB (named new_tarB) is also included. * Orthologs identified by dual-BLAST. ** Orthologs identified by Phylogenetic analysis (detail in figure 1). *** ORFs which the extension (new_tarB) are based.

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Additional File 3:

Annotations of tar/tag orthologs in NCBI. NCBI annotations for tar/tag orthologs are shown here. Because of high homologous, tarA/tagA/tarB/tagB have been already annotated as teichoic acid biosynthesis protein, while other ORFs have not been well annotated.

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Additional File 4:

full size genomic organization image. The top line of this figure is the divergon organization of tar and tag in B. subtilis W23 and 168 as a reference. The following six lines represented in arrows are graphic demonstration of genomic organization of the six S. aureus strains. Arrows in different colours represent different genes as illustrated by the colour table at the bottom. The length of each arrow is defined accurately by the scale, demonstrating the exact amino acid length of each gene. Figures below the arrows denote the GI numbers of corresponding gene. Figures between the arrows denote gap sizes in nucleotide unit between adjacent genes. Noting that, the black dots between some arrows denote the distances of corresponding genes, which are too long to illustrate by the normal scale. BLAST hits are also shown for each gene below. All six S. aureus strains share a similar genomic organization, which is quite different from their B. subtilis W23 and 168 counterparts.

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