Additional File 5.

Comparison of different normalization methods: Coefficients of variation (CV) of technical replicates of Applied Biosystems microarrays. Data on liver sample are shown [8,12]as a representative example. All 33,096 features are represented in this plot. Coefficients of variation (CV) across four technical replicates were calculated using data normalized by different normalization methods, and plotted as a function of average gene expression level. Different normalization methods showed little difference in CV distribution across technical replicates.

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Wang et al. BMC Genomics 2006 7:59   doi:10.1186/1471-2164-7-59