A co-expression network of the Cell Cycle dataset. For all panels in the figure: blue color represents members of the rRNA processing module, yellow color represents members of the protein synthesis module and red color represents members of the ubiquitin pathway. (A) A hierarchical clustering of the topological overlap matrix for the CC dataset. (B) A drawn network of gene co-expression from the CC dataset. A drawn network of gene co-expression from the DD dataset. Edges were computed from the Pearson correlation coefficients. Network structure was drawn in Pajek . Each gene is represented as a dot. Edges are drawn as grey lines. Colored dots belong to the module that their color indicates and grey dots indicate all other genes in the network. (C-E) Correlation plots showing the relationship between gene group connectivity and essentiality for rRNA processing, protein synthesis and ubiquitin from the CC network respectively. On the y axis of these plots is the percentage of genes determined to be essential in yeast. The number of essential genes in each module/total number of genes in each module was: 154/300 = 51.3 (C), 105/398 = 26.4 (D), 38/312 = 12.2 (E). (F-H) Relationship between the average blastp score of a node and k for the same module members listed in C-E. On the y axis of these plots is the average log(e score) of genes within that bin. For plots C-H, the connectivity within each module for each gene was determined and each gene rank ordered by connectivity.
Carlson et al. BMC Genomics 2006 7:40 doi:10.1186/1471-2164-7-40