The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

doi:10.1186/1471-2164-7-313

BMC Genomics

Volume 7

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DeMott MS
Cosgrove JP
Begley TJ
Samson LD
Dedon PC

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Dedon PC
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Research article

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

Rebecca C Fry¹^,2^* , Michael S DeMott¹^* , Joseph P Cosgrove¹^,3 , Thomas J Begley⁴ , Leona D Samson¹^,2 and Peter C Dedon¹^,2

¹Department of Biological Engineering, Massachusetts Institute of Technology, NE47-277, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

²Center for Environmental Health Sciences, Massachusetts Institute of Technology, 56-235, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

³Novartis Institute for Biomedical Research, 250 Massachusetts Ave., 3C-141, Cambridge, MA 02139, USA

⁴University of Albany, Gen*NY*Sis Center, Room 211, 1 Discovery Drive, Rensselear, NY 12144-3456, USA

author email corresponding author email* Contributed equally

BMC Genomics 2006, 7:313doi:10.1186/1471-2164-7-313


Published:	12 December 2006

Additional files

Additional File 1:

Differential enrichment of GO categories identified in the comparison of yeast responses to enediynes and γ-radiation. The table lists the gene ontology categories identified as significantly enriched within the four sectors identified in the comparison of the enediynes response to that of γ-radiation.

Format: PDF Size: 57KB Download file

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Additional File 2:

GO categories identified as associated with single-strand or double-strand damage. The table is a list of the gene ontology categories enriched in the gene sets that were identified as associated with single-strand or double-strand damage.

Format: PDF Size: 48KB Download file

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Additional File 3:

Cytotoxicity dose-response curves for S. cerevisiae strain DBY747 treated with enediynes. The figure plots the cytotoxicity dose-response curve for exposure of strain DBY747 to enediynes.

Format: PDF Size: 157KB Download file

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Additional File 4:

Cytotoxicity dose-response curves for S. cerevisiae strain BY4741 treated with enediynes. The figure plots the cytotoxicity dose-response curve for exposure of strain BY4741 to enediynes.

Format: PDF Size: 125KB Download file

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