Figure 5.

Global transcriptional response to MMS or γ-ray. (A) Hierarchical clustering of 714 genes with at least one transcriptional modulation of 3-fold or greater upon exposure to MMS. S. cerevisiae cultures were exposed to one of three doses of MMS (0,001%, 0.01%, or 0.1% (v/v)) and their global transcriptional response was compared to that of control cells not exposed to MMS. (B) Hierarchical clustering results for 482 Saccharomyces cerevisiae genes with at least one transcriptional modulation of 3-fold or greater in response to γ-ray exposure. S. cerevisiae cultures were exposed to one of three doses of γ-ray (1 Gy, 10 Gy, or 100 Gy) and their global transcriptional response was compared to that of control cells not exposed to γ-ray. Six smaller clusters (A-F) are highlighted because they showed a dose-dependent response (either monotonically increasing, monotonically decreasing, or biphasic) to either MMS or γ-ray.